4-Chloro-2-fluorophenylacetonitrile

Base Information

Chemical Name:4-Chloro-2-fluorophenylacetonitrile
CAS No.:75279-53-7
Molecular Formula:C8H5ClFN
Molecular Weight:169.586
Hs Code.:2926909090
European Community (EC) Number:642-783-7
UNII:XX6QFR93JR
DSSTox Substance ID:DTXSID40371448
Wikidata:Q72451096
Mol file:75279-53-7.mol

Synonyms:75279-53-7;4-Chloro-2-fluorophenylacetonitrile;2-(4-chloro-2-fluorophenyl)acetonitrile;4-Chloro-2-fluorobenzyl cyanide;4-chloro-2-fluorobenzeneacetonitrile;Benzeneacetonitrile, 4-chloro-2-fluoro-;(4-chloro-2-fluoro-phenyl)-acetonitrile;MFCD01312758;EC 642-783-7;2-Fluoro-4-chlorobenzyl cyanide;XX6QFR93JR;SCHEMBL444029;2-fluoro-4-chlorobenzylcyanide;DTXSID40371448;4-chloro-2-fluoro-benzyl cyanide;CHEBI:194655;RTQOANCZEAIDEZ-UHFFFAOYSA-N;4-chloro-2-fluoro-phenylacetonitrile;4-chloro-2-fluorophenyl acetonitrile;(4-chloro-2-fluorophenyl)acetonitrile;AKOS006229605;AC-1175;AM61636;PS-8713;2-(4-chloro-2-luorophenyl)acetonitrile;2-(4-Cloro-2-fluorophenyl)acetonitrile;2-(2-Fluoro-4-chlorophenyl)acetonitrile;SY021882;2-(2-fluoro-4-chlorophenyl) acetonitrile;A9597;CS-0015955;FT-0608600;EN300-342391;J-505933;Z1201620925

Suppliers and Price of 4-Chloro-2-fluorophenylacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-2-fluorobenzeneacetonitrile
10g
$ 120.00

TRC
4-Chloro-2-fluorobenzeneacetonitrile
1g
$ 55.00

SynQuest Laboratories
4-Chloro-2-fluorophenylacetonitrile 95%
25 g
$ 61.00

SynQuest Laboratories
4-Chloro-2-fluorophenylacetonitrile 95%
100 g
$ 232.00

SynQuest Laboratories
4-Chloro-2-fluorophenylacetonitrile 95%
5 g
$ 18.00

Crysdot
2-(4-Chloro-2-fluorophenyl)acetonitrile 98%
25g
$ 95.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzyl cyanide
10 g
$ 80.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzyl cyanide
5 g
$ 50.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzyl cyanide
50 g
$ 250.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzyl cyanide
25 g
$ 150.00

Total 60 raw suppliers

Chemical Property of 4-Chloro-2-fluorophenylacetonitrile

Chemical Property:

Vapor Pressure:0.025mmHg at 25°C
Melting Point:37-41℃
Refractive Index:1.528
Boiling Point:247.9 ºC at 760 mmHg
Flash Point:103.7 ºC
PSA：23.79000
Density:1.286 g/cm³
LogP:2.54518
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:169.0094550
Heavy Atom Count:11
Complexity:174

Purity/Quality:

99.9% ^*data from raw suppliers

4-Chloro-2-fluorobenzeneacetonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s): T,Xn,C
Hazard Codes:T,C,Xn
Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)F)CC#N
Uses 4-Chloro-2-fluorobenzeneacetonitrile is an intermediate used to prepare RG7388, a potent and selective p53-MDM2 inhibitor.

Technology Process of 4-Chloro-2-fluorophenylacetonitrile

There total 5 articles about 4-Chloro-2-fluorophenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 4-chloro-1-(2,2-difluorovinyl)-2-fluorobenzene

: 75279-53-7
2-(4-chloro-2-fluoro-phenyl)acetonitrile

Guidance literature:: With ammonium hydroxide; In acetonitrile; at 60 ℃; for 24h; Sealed tube; Green chemistry;
DOI:10.1021/acs.orglett.1c04336