7528-78-1

Basic information

• Product Name: TRIS(2-CYANOETHYL)AMINE 99+%
• Synonyms: TRIS(2-CYANOETHYL)AMINE 99+%;3,3',3''-Nitrilotrispropanenitrile
• CAS NO: 7528-78-1
• Molecular Formula: C₉H₁₂N₄
• Molecular Weight: 176.21838
• Product Categories: Dinitriles & Trinitriles;Trinitriles
• Mol File: 7528-78-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 60 °C
• Boiling Point: 140 °C / 10mmHg
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: TRIS(2-CYANOETHYL)AMINE 99+%(CAS DataBase Reference)
• NIST Chemistry Reference: TRIS(2-CYANOETHYL)AMINE 99+%(7528-78-1)
• EPA Substance Registry System: TRIS(2-CYANOETHYL)AMINE 99+%(7528-78-1)

Safety Data

• RIDADR: UN 2923 8/6.1/PG III
• HazardClass: 8/6.1
• PackingGroup: III
• Hazardous Substances Data: 7528-78-1(Hazardous Substances Data)

Usage

General Description

TRIS(2-Cyanoethyl)amine 99+% is a chemical compound renowned for its high purity, often used in a variety of scientific applications. Characterized by its three cyanoethyl groups attached to a nitrogen atom, this amine is a valuable tool in chemical synthesis due to its flexibility and the presence of multiple functional groups. TRIS(2-CYANOETHYL)AMINE 99+%'s cyanoethyl groups can be manipulated to form a range of other moieties, often through the use of chemical reduction or addition reactions. While specific properties such as melting point, boiling point, and density can vary based on the supplier, it's important to handle this compound with care as it may be irritable to eyes, skin, and other mucous membranes, following scientific safety protocols to minimize any potential risks.

Upstream product

• 107-13-1 acrylonitrile 
• 7664-41-7 ammonia 

Downstream Products

• 66670-10-8 3,3'-(phenethylazanediyl)dipropanenitrile 
• 27843-14-7 3,3'-(cyclohexylazanediyl)dipropanenitrile 
• 98846-86-7 trimethyl 4,4',4''-tritosyl-7,7',7''-nitrilotri(4-azaheptanoate) 
• 98846-89-0 4,4',4''-tritosyl-7,7',7''-nitrilotri(4-azaheptanenitrile) 
• 98846-87-8 4,4',4''-tritosyl-7,7',7''-nitrilotri(4-azaheptanol) 
• 362613-34-1 tris[3-(N-methylamino)propyl]amine 

Relevant articles and documents

Parent-amido (NH2) palladium(II) complexes: Synthesis, reactions, and catalytic hydroamination

The treatment of [PdL3(NH3)](OTf)n (n = 1; L3 = (PEt3)2(Ph), (2,6-(Cy2PCH2)2C6H3), n = 2; L3 = (dppe)(NH3)) with NaNH2 in tetrahydrofuran at ambient temperature or -78 °C afforded the dimeric and monomeric parent-amido palladium(II) complexes anti-[Pd(PEt3)(Ph)(μ-NH2)]2 (1), [Pd(dppe)(μ-NH2)]2(OTf)2 (2), and Pd(2,6-(Cy2PCH2)2C6H3)(NH2) (3), respectively. The molecular structures of the amido-bridged (μ-NH2) dimeric complexes 1 and 2 were determined by single-crystal X-ray crystallography. The monomeric amido complex 3 reacted with trace amounts of water to give a hydroxo complex, Pd(2,6-(Cy2PCH2)2C6H3)(OH) (4). Exposing complex 3 to an excess of water resulted in the complete conversion of the complex into two species [Pd(2,6-(Cy2PCH2)2C6H3)(OH2)]+ and [Pd(2,6-(Cy2PCH2)2C6H3)(NH3)]+. Complex 3 reacted with diphenyliodonium triflate ([Ph2I]OTf) to give the aniline complex [Pd(2,6-(Cy2PCH2)2C6H3)(NH2Ph)]OTf. The reaction of 3 with phenylacetylene (HCCPh) yielded a palladium(II) acetylenide Pd(2,6-(Cy2PCH2)2C6H3)(CCPh) (5), quantitatively, along with the liberation of ammonia. The reaction of 3 with dialkyl acetylenedicarboxylate yielded diastereospecific palladium(II) vinyl derivatives (Z)-Pd(2,6-(Cy2PCH2)2C6H3)(CRCR(NH2)) (R = CO2Me (6a), CO2Et (6b)). The reaction of complexes 6a and 6b with p-nitrophenol produced Pd(2,6-(Cy2PCH2)2C6H3)(OC6H4-p-NO2) (7) and cis-CHRCR(NH2), exclusively. Reactions of 3 with either dialkyl maleate (cis-(CO2R)CHCH(CO2R)) (R = CH3, CH2CH3) or cis-stilbene (cis-CHPhCHPh) did not result in any addition product. Instead, isomerization of the cis-isomers to the trans-isomers occurred in the presence of catalytic amounts of 3. Complex 3 reacted with a stoichiometric amount of acrylonitrile (CH2CHCN) to generate a metastable insertion product, Pd(2,6-(Cy2PCH2)2C6H3)(CH(CN)CH2NH2). On the other hand, the reaction of 3 with an excess of acrylonitrile slowly produced polymeric species of acrylonitrile. The catalytic hydroamination of olefins with NH3 was examined in the presence of Pd(2,6-(Cy2PCH2)2C6H3)(OTf), producing a range of hydroaminated products of primary, secondary, and tertiary amines with different molar ratios of more than 99% overall yield. A mechanistic feature for the observed catalytic hydroamination is described with regard to the aminated derivatives of palladium(II).