75280-06-7

Basic information

• Product Name: ethyl α-(methylthio)phenylacetate
• Synonyms: ethyl α-(methylthio)phenylacetate
• CAS NO: 75280-06-7
• Molecular Weight: 210.297
• Mol File: 75280-06-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: ethyl α-(methylthio)phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl α-(methylthio)phenylacetate(75280-06-7)
• EPA Substance Registry System: ethyl α-(methylthio)phenylacetate(75280-06-7)

Safety Data

• Hazardous Substances Data: 75280-06-7(Hazardous Substances Data)

Upstream product

• 4455-14-5 ethyl 2-(methylsulfinyl)acetate 
• 71-43-2 benzene 
• 74-93-1 methylthiol 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 32368-19-7 1,2-diphenyl-2-methylthio-1-ethanone 
• 101-97-3 Ethyl 2-phenylethanoate 
• 82751-11-9 diethyl (methylsthio)phenylmalonate 
• 5188-07-8 sodium thiomethoxide 
• 145628-18-8 ethyl 2-chloro-2-methylthio-acetate 

Downstream Products

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 141869-55-8 ethyl α,α-bis(methylthio)phenylacetate 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 1521187-12-1 ethyl methylsulfinylphenylacetate 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 97611-70-6 ethyl α-methylthio-α-phenyl-3,4-dimethoxyphenylacetate 
• 97611-85-3 6,7-Dimethoxy-2,4-dimethyl-4-phenyl-1,4-dihydro-2H-isoquinolin-3-one 
• 97611-54-6 1,2,3,4-terahydro-6,7-dimethoxy-2,4-dimethyl-4-phenylisoquinoline 
• 97611-72-8 2-(3,4-Dimethoxy-phenyl)-2-phenyl-propionic acid ethyl ester 
• 97611-77-3 2-(3,4-Dimethoxy-phenyl)-N-methyl-2-phenyl-propionamide 
• 97611-73-9 2-(3,4-dimethoxyphenyl)-2-phenylpropionic acid 
• 97611-71-7 ethyl α-phenyl-3,4-dimethoxyphenylacetate 
• 35809-43-9 Phenyl-(α-methylthio)acetaldehyd 
• 101-97-3 Ethyl 2-phenylethanoate 

Relevant articles and documents

On the thermal Pummerer rearrangement of substituted sulfoxides

Sulfoxides bearing thioester and ester groups at the position under heating at ca. 140C undergo Pummerer thermal rearrangement. However, for sulfonyl sulfoxide, a complex mixture of products is formed. Plausible mechanism is advanced(equation presented. 2013

SYNTHESIS OF SUBSTITUTED TRANS-1,6-DIMETHYLBICYCLONON-2-ENES USING A CLAISEN REARRANGEMENT OF α-(THIOALKOXY)ESTERS

The Claisen rearrangement of α-(thioalkoxy)esters provided access to substituted trans-1,6-dimethylbicyclonon-2-enes characteristic of the CD rings of the cucurbitanes.

Synthesis of Ethyl Arylacetates by Means of Friedel-Crafts Reaction of Aromatic Compounds with Ethyl α-Chloro-α-(methylthio)acetate

Friedel-Crafts reaction of aromatic compounds with ethyl α-chloro-α-(methylthio)acetate (1) gave ethyl α-(methylthio)arylacetates (2), which were readily converted into ethyl arylacetates (3) by reductive desulfurization with Raney nickel or zinc dust-acetic acid.The reactions were applied to the syntheses of ibufenac (5) and alclofenac (6), which are anti-inflammatory agents.