752934-57-9

Upstream product

• 75218-44-9 N-(3-Thienyl-β-ethyl)-3,4-dimethoxyphenylacetamide 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 59311-67-0 2-(3-thienyl)ethylamine 
• 75218-46-1 7-(3',4'-dimethoxybenzyl)-4,5-dihydrothieno<2,3-c>pyridine hydrochloride 

Downstream Products

• 75218-48-3 7-(3,4-Dimethoxybenzyl)-4,5,6,7-tetrahydrothieno<2,3-c>pyridine hydrochloride 

Relevant academic research and scientific papers

NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES

The present invention relates to indole and pyrrolopyridine amide derivatives of formula (I) wherein R1, R 2, R 3, U, V, W, X, Y, Z and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

STUDIES ON HETEROCYCLIC COMPOUNDS VI. Synthesis of Thiophene Isoesters of Protoberberine Alkaloids

Synthesis of thiophene isosters of protoberberine alkaloids (6, 12, 19) is described.The Mannich type reaction of the tetrahydroisoquinolines (5, 11) and the thienopyridine (18) with formaldehyde in glacial acetic acid afforded the title compounds.Cyclization of the tetrahydroisoquinoline derivative (23) failed to furnish the D-ring protoberberine isoster (25), but gave an unexpected product, the oxazepinoisoquinoline derivative (24).The conversion of the compound (24) to the 2-substituted isoquinoline (27) is also described.