752956-75-5

Usage

Physical state

Colorless, viscous liquid

Use

Chiral building block in the synthesis of pharmaceuticals and fine chemicals

Properties

Antibacterial and antifungal

Applications

Medical and personal care products, industrial and research applications

Synthesis

Ring-opening reaction of azetidine with a chirally pure nucleophile.

Upstream product

• 152537-03-6 tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate 
• 183062-96-6 2-(1-(tert-butoxycarbonyl)azetidin-3-yl)acetic acid 

Relevant academic research and scientific papers

1H-[1,2,3]TRIAZOLO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES

The invention relates to 1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile derived Cathepsin S inhibitors of Formula (I), wherein R1 is H or (C1-3)alkyl; R2 is halogen or (C1-4)alkyl, optionally substituted with one or more halogens; n is 1 -3; X is O or CH2; U, V and W are CH; or one of U, V and W is N; Y is a group capable of interacting with the Sn....S2 substites of the active site of Cathepsin S; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.