75299-08-0Relevant academic research and scientific papers
Intramolecular α-amidoalkylation of an olefin for the synthesis of a useful prostaglandin intermediate
Li, Tsung-Tee,Lesko, Particia,Ellison, Robert H.,Subramanian, N.,Fried, John H.
, p. 111 - 115 (2007/10/02)
The α,β-unsaturated aldehyde 1 is an important intermediate in the preparation of a number of prostaglandins such as prostaglandin C2 and thromboxane B2.A method was developed by starting with the ene lactone 3 and using an intramolecular α-amidoalkylation reaction as the key step that made available this useful molecule in six operations.Formation of the lactam 15, as well as its final conversion to the target aldehyde 1, will be discussed.
