753017-91-3Relevant academic research and scientific papers
Catalytic enantio- and diastereoselective aldol reactions of glycine-derived silicon enolate with aldehydes: An efficient approach to the asymmetric synthesis of anti-β-hydroxy-α-amino acid derivatives
Kobayashi, Jun,Nakamura, Masayuki,Mori, Yuichiro,Yamashita, Yasuhiro,Kobayashi, Shu
, p. 9192 - 9193 (2004)
We have developed an efficient method for the asymmetric synthesis of anti-β-hydroxy-α-amino acid derivatives based on highly enantio- and diastereoselective aldol reactions of the silicon enolate derived from N-trifluoroacetylglycinate with aldehydes using a chiral zirconium catalyst. The resulting N-trifluoroacetyl group is easily cleaved under either acidic or basic conditions and can be used directly as a protecting group for further transformations. Copyright
