753017-93-5

Upstream product

• 15890-72-9 laurylmagnesium bromide 
• 753017-92-4 (4S,5R,1'E)-4-(3'-acetoxypent-1'-enyl)-2-(4''-methoxyphenyl)-5-trifluoroacetylamino-[1,3]dioxane 
• 753017-91-3 (4S,5R,1'E)-4-[3'-(tert-butyldiphenylsiloxy)pent-1'-enyl]-2-(4''-methoxyphenyl)-5-trifluoroacetylamino-[1,3]dioxane 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 

Downstream Products

• 753017-95-7 (4S,5R,1'E)-5-amino-2-(4''-methoxyphenyl)-4-(pentadec-1'-enyl)-[1,3]dioxane 

Relevant academic research and scientific papers

Catalytic enantio- and diastereoselective aldol reactions of glycine-derived silicon enolate with aldehydes: An efficient approach to the asymmetric synthesis of anti-β-hydroxy-α-amino acid derivatives

We have developed an efficient method for the asymmetric synthesis of anti-β-hydroxy-α-amino acid derivatives based on highly enantio- and diastereoselective aldol reactions of the silicon enolate derived from N-trifluoroacetylglycinate with aldehydes using a chiral zirconium catalyst. The resulting N-trifluoroacetyl group is easily cleaved under either acidic or basic conditions and can be used directly as a protecting group for further transformations. Copyright