75305-80-5Relevant academic research and scientific papers
Insights into the binding of thiosemicarbazone derivatives with human serum albumin: Spectroscopy and molecular modelling studies
Karthikeyan, Subramani,Bharanidharan, Ganesan,Kesherwani, Manish,Mani, Karthikananth,Srinivasan, Narasimhan,Velmurugan, Devadasan,Aruna, Prakasarao,Ganesan, Singaravelu
, p. 1264 - 1281 (2015)
4-[(1Z)-1-(2-carbamothioylhydrazinylidene)ethyl]phenyl acetate [Ace semi],4-[(1Z)-1-(2-carbamothioylhydrazinylidene) ethyl]phenyl propanoate [Pro semi] from the family of thiosemicarbazones derivative has been newly synthesized. It has good anticancer activity as well as antibacterial and it is also less toxic in nature, its binding characteristics are therefore of huge interest for understanding pharmacokinetic mechanism of the drug. The binding of thiosemicarbazone derivative to human serum albumin (HSA) has been investigated by studying its quenching mechanism, binding kinetics and the molecular distance (r) between donor (HSA) and acceptor (thiosemicarbazone derivative) was estimated according to Forster’s theory of non-radiative energy transfer using fluorescence spectroscopy. The binding dynamics has been elaborated using synchronous fluorescence spectroscopy, and the feature of thiosemicarbazone derivative induced structural changes of HSA has been studied by circular dichorism, Fourier transform infrared spectroscopy. Molecular modelling simulations explore the hydrophobic interaction and hydrogen bonding which stabilizes the interaction.
Synthesis of 6-Acetyl-3-alkyl-2-phenyl-chromen-4-ones by Phasetransfer Catalysed Baker-Venkataraman Reaction
Henning, H.-G.,Schwabe, B.,Kernchen, F.,Westphal, G.
, p. 491 - 501 (2007/10/02)
Three of the five partial steps of the Baker-Venkataramansynthesis of flavones (scheme 1) can be flavoured by PTC conditions.In the intermolecular O-acylations of the 4-hydroxyacetophenone 1 (A) and the 5-acetyl-2-hydroxy-acylophenones 3 (C), respectively, the nucleophilicity of the phenolat anions is increased by the PT catalysator.The steric and electronic effects of the substituents in the 5-acetyl-2-benzoyloxy-acylophenones 4 cause the formation of the 6-acetyl-flavones 6 in the phasetransfer catalysed Baker-Venkataraman rearrangement (D) in one step and in good yields.The over-all yields of the 1 -> 6 reactions are not higher than 30percent because of the limiting step (B).This Fries rearrangement of 4-acyloxy-acetophenones 2 affords only 32-62percent of 3 under drastically enhanced conditions.
