75312-57-1 Usage
Chemical compound
1,8-bis(2-diethylaminoethylamino)anthracene-9,10-dione
Type
Fluorescent dye
Function
DNA intercalator
Applications
a. Fluorescence microscopy
b. DNA staining
c. Detection of DNA/RNA in biological samples
Potential use
Cancer therapy
Mechanism of action
Inhibition of topoisomerase enzyme activity
Safety concerns
Toxicity, skin and eye irritation
Handling precautions
Careful handling required due to potential health risks
Check Digit Verification of cas no
The CAS Registry Mumber 75312-57-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,3,1 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 75312-57:
(7*7)+(6*5)+(5*3)+(4*1)+(3*2)+(2*5)+(1*7)=121
121 % 10 = 1
So 75312-57-1 is a valid CAS Registry Number.
InChI:InChI=1/C26H36N4O2/c1-5-29(6-2)17-15-27-21-13-9-11-19-23(21)26(32)24-20(25(19)31)12-10-14-22(24)28-16-18-30(7-3)8-4/h9-14,27-28H,5-8,15-18H2,1-4H3
75312-57-1Relevant articles and documents
Anti-cancer compounds
-
, (2008/06/13)
Compounds of formula (I) STR1 in which R1, R2, R3 and R4 are each separately selected from hydrogen, X, NH--A--NHR and NH--A--N(O)R'R" wherein X is hydroxy, halogeno, amino, C1-4 alkoxy or C2-8 alkanoyloxy, A is a C2-4 alkylene group with a chain length between NH and NHR or N(O)R'R" of at least 2 carbon atoms and R, R' and R" are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups in which the carbon atom attached to the nitrogen atom does not carry a hydroxy group and no carbon atom is substituted by two hydroxy groups, or R' and R" together are a C2-6 alkylene group which with the nitrogen atom to which R" and R" are attached forms a heterocyclic group having 3 to 7 atoms in the ring, but with the proviso that at least one of R1 to R4 is a group NH--A--N(O)R'R", and physiologically acceptable salts thereof are of value in the treatment of cancer.
