75318-77-3

Usage

InChI:InChI=1/C16H15N3O2/c1-21-13-7-4-6-11(9-13)15-17-16(19-18-15)14-8-3-2-5-12(14)10-20/h2-9,20H,10H2,1H3,(H,17,18,19)

Upstream product

• 76217-30-6 4-<(3-methoxybenzylidene)hydrazino>-1H-2,3-benzoxazine 
• 591-31-1 3-methoxy-benzaldehyde 
• 19722-31-7 4-hydrazino-1H-2,3-benzoxazine 

Downstream Products

• 86656-54-4 3-(3-methoxyphenyl)-5-(2-octanoyloxymethylphenyl)-1H-1,2,4-triazole 
• 76217-33-9 2-<3-(3-methoxyphenyl)-s-triazol-5-yl>benzaldehyde 

Relevant academic research and scientific papers

3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and uses

3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula STR1 wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R5 CO-- wherein R5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R1, R2 and R3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R2 and R3 together may represent a methylenedioxy group, and R4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R5 CO-- group wherein R5 contains 4 or less carbon atoms, R4 must contain 5 or more carbons. These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.

1,2,4-Triazole derivatives as antifertility agents and pharmaceutical compositions containing them

Novel 1,2,4-triazole derivatives are described having the following formula STR1 wherein R represents hydrogen or methyl, R1 stands for hydrogen or (C1 -C4)alkyl, or R and R1 taken together may represent a furth

A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles

A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.