75319-02-7

Basic information

• Product Name: 4-CHLORO-2-METHYLBENZHYDRAZIDE
• Synonyms: 4-CHLORO-2-METHYLBENZHYDRAZIDE;4-chloro-2-methylbenzohydrazide
• CAS NO: 75319-02-7
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.62
• Mol File: 75319-02-7.mol

Chemical Properties

• Appearance: /
• Density: 1.271g/cm³
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-CHLORO-2-METHYLBENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-METHYLBENZHYDRAZIDE(75319-02-7)
• EPA Substance Registry System: 4-CHLORO-2-METHYLBENZHYDRAZIDE(75319-02-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 75319-02-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-methylbenzhydrazide is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and properties contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 4-Chloro-2-methylbenzhydrazide is utilized as an intermediate for the synthesis of agrochemicals. Its anti-microbial and anti-fungal properties make it a valuable component in the development of products for crop protection and pest control.
Used in Industrial and Agricultural Applications:
4-Chloro-2-methylbenzhydrazide is used as an ingredient in certain industrial and agricultural applications due to its anti-microbial and anti-fungal properties. It can be incorporated into products to prevent the growth of harmful microorganisms, thereby enhancing the shelf life and quality of the products.

InChI:InChI=1/C8H9ClN2O/c1-5-4-6(9)2-3-7(5)8(12)11-10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 21900-44-7 4-chloro-2-methylbenzoyl chloride 
• 99585-12-3 4-chloro-2-methylbenzoic acid methyl ester 

Downstream Products

• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 1003849-08-8 4-amino-5-(4-chloro-2-methylphenyl)-4H-1,2,4-triazole-3-thiol 
• 1003849-06-6 2-(4-chloro-2-methylbenzoyl)hydrazinecarbodithioic acid potassium salt 
• 75318-76-2 3-(4-Chloro-2-methyl-phenyl)-5-(3-methoxy-phenyl)-1H-[1,2,4]triazole 
• 85303-94-2 3-(4-chloro-2-methylphenyl)-5-phenyl-s-triazole 

Relevant articles and documents

Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi

Abstract: A novel series of picarbutrazox-inspired oxadiazole hybrids was synthesized and the derivatives’ biological activity against phytopathogenic fungi was investigated. The molecules were designed by retaining the active fragment of tetrazolyl phenyloxime ether of lead compound picarbutrazox, while introducing the potentially active oxadiazole-derived fragment. Bioassay results revealed that some of the title compounds showed potent in vivo antifungal activities to control cucumber downy mildew. Therefore, this novel oxadiazole phenyloxadiazole derivative can be used as a potential antifungal agent to control cucumber downy mildew and other phytopathogenic fungi for crop protection. Graphic abstract: [Figure not available: see fulltext.].

Synthesis and evaluation of antioxidant properties of novel 1,2,4-triazole-based schiff base heterocycles

A series of 1,2,4-triazole-based Schiff base heterocyclic compounds (5a-f and 8a-i) and phenethylamines (7a-h) were synthesized and evaluated for antioxidant properties by free-radical scavenging, anti-hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage. Compounds 7c, 7d, 7h, 8b, and 8i showed promising DPPH? radical scavenging activity with the level of inhibition between 86.8% and 94%. Compounds 8a, 8b, 8d, 8g, and 8i were effective against the oxidative hemolysis of human erythrocytes and lipid peroxidation, in a dose-dependent manner, with IC50 values in the range of 55.7-80.7 and 53.2-81.2 μg/mL, respectively. Compounds 8a and 8b were effective against oxidative damage on erythrocyte ghost membrane proteins, and 8g and 8i were able to protect against DNA oxidative damage. 1,2,4-Triazole based Schiff base heterocycles (5a-f, 8a-i) and phenethylamines (7a-h) were synthesized and evaluated for their antioxidant properties by free-radical scavenging, anti-hemolytic activity, lipid peroxidation, and their protective effects against DNA oxidative damage.

A New Class of Nonhormonal Pregnancy-Terminating Agents. Synthesis and Contragestational Activity of 3,5-Diaryl-s-triazoles

A series of 3,5-diaryl-s-triazoles were synthesized and evaluated as postimplantation contragestational agents.The introduction of various substituents (e.g., an o-alkyl chain on one phenyl and a m-alkoxy group on the other) was found to increase the potency.Several compounds with very high pregnancy-terminating activity in both hamsters and rats were obtained.One of these, 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-s-triazole, DL 111 (36), was selected for detailed evaluation in various animal species.A synthetic scheme for the preparation of these compounds and preliminary structure-activity relationships are presented.