99585-12-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-methyl-benzoic acid methyl ester is used as a chemical intermediate for the preparation of urea and pyrazole compounds. These compounds act as α7 Nicotinic acetylcholine receptor agonists, which are beneficial in the treatment of cognitive impairment. The agonist activity of these compounds helps to improve cognitive function and memory in patients with cognitive disorders.

Upstream product

• 7499-07-2 4-chloro-2-methylbenzoic acid 
• 67-56-1 methanol 
• 40137-29-9 2-methyl-4-chlorobenzaldehyde 
• 74-88-4 methyl iodide 

Downstream Products

• 145908-29-8 methyl 2-(bromomethyl)-4-chlorobenzoate 
• 1040720-97-5 N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-pyrrolidin-1-ylbutyramide 
• 1040721-09-2 N-[5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide formate salt 
• 1608129-76-5 5-amino-3-(4-chloro-2-methylphenyl)pyrazole-1-carboxylic acid tert-butyl ester 
• 1608129-65-2 4-pyrrolidin-1-yl-piperidine-1-carboxylic acid [5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-yl]amide 
• 1608129-80-1 C₁₉H₂₂ClN₃O₄ 
• 1040724-41-1 5-(4-chloro-2-methylphenyl)-2H-pyrazol-3-ylamine 
• 73206-63-0 (4-isobutyl-2-methylphenyl)methanol 

Relevant academic research and scientific papers

N-Heterocyclic carbene catalyzed esterification of aromatic aldehydes with alcohols under aerobic conditions

A simple, organocatalytic procedure for the direct oxidative esterification of a variety of aromatic aldehydes with alcohols has been described that affords the corresponding aromatic esters in high yields. The method employs N-heterocyclic carbenes as catalysts and molecular O2 as an oxidant under ambient conditions.

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

A series of analogs of the immunomodulary drugs lenalidomide (1) and pomalidomide (2), in which the amino group is replaced with various isosteres, was prepared and assayed for immunomodulatory activity and activity against cancer cell lines. The 4-methyl and 4-chloro analogs 4 and 15, respectively, displayed potent inhibition of tumor necrosis factor-α (TNF-α) in LPS-stimulated hPBMC, potent stimulation of IL-2 in a human T cell co-stimulation assay, and anti-proliferative activity against the Namalwa lymphoma cell line. Both of these analogs displayed oral bioavailability in rat.

Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions

The inventions disclosed herein relate to the discovery of the use of compounds having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents