7533-07-5

Basic information

• Product Name: 2-ACETYL-4-METHYLTHIAZOLE, 97%
• Synonyms: Ethanone, 1-(4-methyl-2-thiazolyl)-;1-(4-methyl-1,3-thiazol-2-yl)ethanone
• CAS NO: 7533-07-5
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• EINECS: 616-211-1
• Product Categories: Heterocyclic Compounds;Building Blocks;C3 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Thiazoles
• Mol File: 7533-07-5.mol

Chemical Properties

• Melting Point: 34-38 °C(lit.)
• Boiling Point: 233.9°C at 760 mmHg
• Flash Point: 90 °C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 0.0544mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 2-ACETYL-4-METHYLTHIAZOLE, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-4-METHYLTHIAZOLE, 97%(7533-07-5)
• EPA Substance Registry System: 2-ACETYL-4-METHYLTHIAZOLE, 97%(7533-07-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 7533-07-5(Hazardous Substances Data)

Usage

Uses

Used in Flavor and Fragrance Industry:
2-Acetyl-4-methylthiazole, 97% is used as a flavoring agent for adding a savory, meaty, and roasted note to food products. Its unique aroma makes it a valuable ingredient in enhancing the taste and smell of various food items.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-Acetyl-4-methylthiazole is utilized in the development and production of various medications. Its chemical properties make it a useful component in the synthesis of different drug compounds.
Used as a Research Chemical:
2-Acetyl-4-methylthiazole, 97% also serves as a research chemical in numerous scientific studies. Its unique properties and reactivity make it a valuable tool for researchers in various fields, including chemistry, biology, and materials science.

InChI:InChI=1/C6H7NOS/c1-4-3-9-6(7-4)5(2)8/h3H,1-2H3

Upstream product

• 693-95-8 4-Methylthiazole 
• 925-90-6 ethylmagnesium bromide 
• 100675-54-5 2-hydroxy-4-formyl-2,5-dimethyl-2,3-dihydro-1,4-thiazine 
• 141-78-6 ethyl acetate 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 142941-95-5 3-Acetonyl-4-methyl-1,3-thiazolium chloride 
• 142731-30-4 4-formyl-2,5-dimethyl-1,4-thiazine 

Downstream Products

• 1242535-42-7 2-(N-benzylisopropyl)aminoethyl-4-methyl-2-thiazolylketone 
• 7531-83-1 2-bromo-1-(4-methyl-thiazol-2-yl)-ethanone 
• 855628-40-9 2-[1-(hydroxyimino)ethyl]-4-methyl-thiazole 
• 855628-40-9 2-[1-(hydroxyimino)ethyl]-4-methyl-thiazole 
• 1242535-46-1 2-(N-benzylmethyl)aminoethyl-4-methyl-2-thiazolylketone 
• 15679-12-6 2-ethyl-4-methyl-1,3-thiazole 

Relevant articles and documents

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki's against SYK and potent inhibition in mast cell degranulation assays.

THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Reactions of 2-acylthiazolium salts with N-arylhydroxylamines

2-Acylthiazolium salts, easily obtained by alkylation of the corresponding 2-acylthiazoles with methyl triflate, react with N- arylhydroxylamines to furnish the O-acyl derivatives of relevance in the induction of cancer by aromatic mines.

Aqueous base induced selective transformations of 3-(2-oxoalkyl) thiazolium cations

The title compounds react with aqueous sodium hydroxide (i) 2%, 1 equiv., (ii) 2%, 2 equiv., and (iii) 8%, 2 equiv., to give 2-hydroxy-2-alkyl/aryl-4-formyl-2,3-dihydro-1,4-thiazines (7), 2-alkyl/aryl-4-formyl-1,4-thiazines (8) and 2-aroylthiazoles (9), r