75333-92-5

Upstream product

• 504-29-0 2-aminopyridine 
• 100-52-7 benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 762-04-9 Diethyl phosphonate 

Relevant academic research and scientific papers

SO 3H -functionalized magnetic Fe 3O 4 nanoparticles as an efficient and reusable catalyst for one-pot synthesis of α -amino phosphonates

Abstract: Nanomagnetic Fe 3O 4@ SiO 2-SO 3H (SO 3H-MNPs) was prepared via grafting sulfonic acid on the silica-coated Fe 3O 4 magnetite nanoparticles (MNPs). The catalytic activi

A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst

Synthesis of amino phosphonates is more important owing to their significant applications in the biological systems. There are few methods already known in the literature to make these molecules; however, known methods have their own disadvantages. In this regard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. In order to find an efficient catalyst for carbene insertion reaction in neat water, a large number of transition metal catalysts were screened, and we found that the [Cu(CH3CN)4]ClO4 was the best catalyst under employed reaction conditions. Using this environmentally benign methodology (copper catalyzed reaction in water), a large number of biologically important amino phosphonates have been synthesized, isolated (37 examples), and characterized using standard analytical and spectroscopic techniques.

Ultrasound mediated synthesis of α-aminophosphonates and 3,4-dihydropyrimidin-2-ones using graphene oxide as a recyclable catalyst under solvent-free conditions

Graphene oxide is utilized as an environmentally friendly and efficient catalyst for an ultrasound mediated multi-component coupling reaction that involves aldehyde, amine/ethylacetoacetate and diethyl phosphite/urea, under solvent-free conditions, leading to the bioactive α-aminophosphonates and 3,4-dihydropyrimidin-2-ones with excellent yield. This journal is

Air-stable zirconocene bis(perfluorobutanesulfonate) as a highly efficient catalyst for synthesis of α-aminophosphonates via Kabachnik-Fields reaction under solvent-free condition

Zirconocene bis(perfluorobutanesulfonate) [Cp2Zr(OSO 2C4F9)2·2H2O] was successfully synthesized by treatment of Cp2ZrCl2 with C4F9SO3Ag, and was found to have the nature of air-stability, water tolerance, high thermal stability and strong Lewis acidity. This complex showed high catalytic efficiency for the synthesis of α-aminophosphonates via Kabachnik-Fields reaction of aldehydes/ketones, amines and diethyl phosphite under mild and solvent-free conditions. Furthermore, it can be reused without loss of activity in a test of five cycles. Compared with our previously reported complex of Cp2Zr(OSO 2C8F17)2·3H 2O·THF, this complex showed better catalytic activity.

Nano Fe3O4 as magnetically recyclable catalyst for the synthesis of α-aminophosphonates in solvent-free conditions

The three component, one-pot synthesis of α-aminophosphonates has been achieved using super magnetic nano iron oxide at 50°C under solvent-free conditions in excellent yields. The major advantages of the present method are high yields, short reaction times, magnetically recyclable catalyst, and solvent-free reaction conditions.

Aminopyridines as amino components in the catalytic synthesis of α-aminophosphonates

6h-Aminophosphonates containing alicyclic, aromatic, and heterocyclic fragments were obtained in high yields by the Kabachnick-Fields reaction of the corresponding carbonyl compounds with 2-, 3- and 4-aminopyridines and diethyl phosphite using tetra- tert

NEW SYNTHETIC METHODOLOGY FOR THE PREPARATION OF SUBSTITUTED 1-ARYL-1-PYRIDYLAMINOMETHANEPHOSPHONIC ACID ESTERS

Esters of 1-phenyl-1-pyridylaminomethanephosphonates generally cannot, or only in poor yields be prepared by the usual methods by treatment of the appropriate Schiff base with diethyl or diphenyl phosphite.However, it was found that these phosphonates are