75338-41-9

Usage

Chemical class

Fluoroquinolone antibiotic

Function

Inhibits bacterial DNA replication and repair

Effective against

Wide range of gram-negative and gram-positive bacteria

Common uses

Treating urinary tract infections, respiratory tract infections, skin infections, and other bacterial diseases

Forms available

Oral and injectable

Precautions

Should be used with caution and under the supervision of a healthcare professional

Purpose

To prevent the growth and spread of bacteria

Side effects

Potential risks if not used properly

Resistance

Minimizing the risk of antibiotic resistance by proper use

Target

Bacterial DNA replication and repair processes

InChI:InChI=1/C17H19F2N3O3/c1-3-21-9-11(17(24)25)16(23)10-8-12(18)15(13(19)14(10)21)22-6-4-20(2)5-7-22/h8-9H,3-7H2,1-2H3,(H,24,25)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 75338-42-0 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 3862-73-5 2,3,4-trifluoroaniline 
• 100501-62-0 ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 79660-46-1 ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 100501-60-8 diethyl 2-((2,3,4-trifluorophenylamino)methylene)malonate 

Relevant academic research and scientific papers

Synthesis and antibacterial evaluation of novel 8-fluoro Norfloxacin derivatives as potential probes for methicillin and vancomycin-resistant Staphylococcus aureus

A series of novel 8-fluoro Norfloxacin derivatives and the hybrids of its piperazinyl derivatives incorporated with 1,3,5-triazine and pyrimidine were synthesized. All the above compounds were evaluated for their antibacterial activity against Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus and methicillin & vancomycin-resistant S. aureus. Among all, compounds having Morpholine, N-methyl/phenyl/benzyl/pyrimidinyl piperazines and n-butylamine substitution at C-7 position, have shown increased potency in comparison to norfloxacin and ciprofloxacin.

NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES

The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.

7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.