75339-70-7Relevant academic research and scientific papers
Determination of Neutral Manufacturing Impurities in Heroin by Capillary Gas Chromatography with Electron Capture Detection after Reduction with Lithium Aluminum Hydride and Derivatization with Heptafluorobutyric Anhydride
Moore, James M.,Allen, Andrew C.,Cooper, Donald A.
, p. 1003 - 1007 (1986)
Neutral byproducts associated with the manufacture of illicit heroin are many and include meconin, 4-acetoxy-3,6-dimethoxyphenanthrene, N,O6-diacetylnorcodeine, 4-acetoxy-3,6-dimethoxy-5-phenanthrene, N,O3,O6-triacetylnormorphine, and 4-acetoxy-3,6-dimethoxy-8-phenanthrene.These N- and O-acetylated impurities, and meconin, are easily isolated from the bulk heroin matrix, after which they are subjected to reduction with lithium aluminum hydride (LiAlH4) followed by derivatization with heptafluorobutyric anhydride (HFBA) in the presence of pyridine.The resultant haptafluorobutyryl (HFB) electrophiles are detected on-column at picogram (pg) levels by using capillary column gas chromatography/electron capture detection (CC/GC/ECD) in the splitless mode.The method is applicable for the in-depth analyses of crudely processed and highly refined heroin samples.
The Oxidation of a Series of Phthalyl Alcohols
Bhattacharjee, Debkumar,Popp, Frank D.
, p. 315 - 320 (2007/10/02)
A series of phthalyl alcohols containing methoxy and methyl substituents were prepared by lithium aluminum hydride reduction of phthalides.Oxidation of the phthalyl alcohols with activated manganese dioxide or with barium manganate gave phthalaldehydes or
