Analytical Chemistry p. 1003 - 1007 (1986)
Update date:2022-08-03
Topics:
Moore, James M.
Allen, Andrew C.
Cooper, Donald A.
Neutral byproducts associated with the manufacture of illicit heroin are many and include meconin, 4-acetoxy-3,6-dimethoxyphenanthrene, N,O6-diacetylnorcodeine, 4-acetoxy-3,6-dimethoxy-5-<2-(N-methylacetamido)ethyl>phenanthrene, N,O3,O6-triacetylnormorphine, and 4-acetoxy-3,6-dimethoxy-8-<2-(N-metnylacetamido)ethyl>phenanthrene.These N- and O-acetylated impurities, and meconin, are easily isolated from the bulk heroin matrix, after which they are subjected to reduction with lithium aluminum hydride (LiAlH4) followed by derivatization with heptafluorobutyric anhydride (HFBA) in the presence of pyridine.The resultant haptafluorobutyryl (HFB) electrophiles are detected on-column at picogram (pg) levels by using capillary column gas chromatography/electron capture detection (CC/GC/ECD) in the splitless mode.The method is applicable for the in-depth analyses of crudely processed and highly refined heroin samples.
View MoreHeliosense Biotechnologies, Inc.
Contact:+86-592-5667290
Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Jurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Wuhan Benjamin Pharmaceutical Chemical Co.,Ltd
Contact:86-27-52341789
Address:Room 1518 B suite, optical valley time square, No 111 Guanshan Road, Hongshan District,Wuhan,Hubei Province,China.
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Doi:10.1016/j.ejmech.2015.05.034
(2015)Doi:10.1021/ja00541a045
(1980)Doi:10.1016/j.ica.2004.03.018
(2004)Doi:10.1039/b809464k
(2008)Doi:10.1021/jo000024o
(2000)Doi:10.1002/chem.202101436
(2021)