75360-68-8Relevant academic research and scientific papers
Non-steroidal antiinflammatory agents. Part VII. Methane sulfonanilides
Schroeder,Lehmann,Rufer,Bottcher
, p. 165 - 172 (2007/10/02)
Synthesis and antiinflammatory activity (rat) of indane derivatives related to the potent antiinflammatory N-(6-phenoxy-5-indanyl) methane sulfonamide are described. The following structure activity relationships can be recognized. Replacement of the O atom of the phenoxy residue by a direct bond, a (substituted) methylene or a carbonyl group only in the latter case led to active compounds. In general, modification of the methane sulfonamide moiety resulted in loss of activity, however, the chloro- and fluoro-methanesulfonamides, as well as the N-acetyl methanesulfonamide proved to be active. When the phenyl ring was replaced by cyclohexyl, naphthyl or heterocyclic ring systems, activities were found only in the pyridyloxy derivatives
Indanyl derivatives and their use
-
, (2008/06/13)
Indanyl derivatives of the formula STR1 wherein AR is phenyl, pyridyl, or phenyl or pyridyl substituted by halogen, alkyl of 1-4 carbon atoms or trifluoromethyl; X is oxygen or a sulfur; R1 is alkyl of 1-4 carbon atoms or alkyl of 1-4 carbon at
