75366-10-8

Usage

Uses

Used in Organic Synthesis:
1-Bromo-2-bromomethyl-3-methyl-benzene is used as an intermediate in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique structure allows for further chemical reactions and modifications, making it a valuable building block in the synthesis of complex organic molecules.
Used in Chemical Reactions:
1-Bromo-2-bromomethyl-3-methyl-benzene is also used as a reagent in chemical reactions, facilitating specific transformations and providing a pathway to desired products. Its presence can influence the course of a reaction and improve the yield of the target molecule.
Used as a Precursor:
1-Bromo-2-bromomethyl-3-methyl-benzene serves as a precursor to other bromoalkyl derivatives, which are important in various chemical applications. Its ability to be converted into a range of different compounds makes it a versatile starting material in the chemical industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Bromo-2-bromomethyl-3-methyl-benzene is used as a key component in the synthesis of certain drugs. Its unique properties enable the development of new medications with specific therapeutic effects.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 1-Bromo-2-bromomethyl-3-methyl-benzene is utilized in the creation of pesticides, herbicides, and other agricultural chemicals. Its role in these applications contributes to the development of effective solutions for crop protection and management.
Safety Precautions:
Due to its hazardous nature, 1-Bromo-2-bromomethyl-3-methyl-benzene should be handled with care and used in a well-ventilated area with appropriate safety precautions to minimize health risks.

Upstream product

• 75366-04-0 2-methyl-1H-cyclopropabenzene 
• 99548-56-8 methyl 2-bromo-6-methyl-benzoate 
• 576-23-8 2,3-dimethylbromobenzene 

Downstream Products

• 200049-46-3 7-bromo-2,3-dihydro-1H-isoindol-1-one 
• 1114904-92-5 (2-bromo-4-methylbenzyl)triphenylphosphonium bromide 

Relevant academic research and scientific papers

Structure Elucidation Using Gas Chromatography-Infrared Spectroscopy/Mass Spectrometry Supported by Quantum Chemical IR Spectrum Simulations

An improved strategy for compound identification incorporating gas chromatography hyphenated with Fourier transform infrared spectroscopy and mass spectroscopy (GC-FTIR/MS) is reported. (Over)reliance on MS may lead either to ambiguous identity or to incorrect identification of a compound. However, the MS result is useful to provide a cohort of possible compounds. The IR result for each tentative compound match was then simulated using molecular modeling, to provide functional group and isomer differentiation information, and then compared with the experimental FTIR result, offering identification based on both MS and IR. Several basis sets were evaluated for IR simulations; Def2-TZVPP was a suitable basis set and correlated well with experimental data. The approach was applied to industrial applications, confirming the isomers of 2,3-bis(thiosulfanyl)-but-2-enedinitrile, bromination products of 1-bromo-2,3-dimethylbenzene, and autoxidative degradation of phenyl-di-tert-butylphosphine.

DIARYLSULFONES AS 5-HT2A ANTAGONISTS

Compounds of formula (I) are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Regioselective Ring Opening in Substituted Benzocyclopropenes. An Alternative or Complementary Mechanism for Electrophilic Substitution Involving Attack at a ? Bond

2-Methylbenzocyclopropene (5) reacts with bromine, iodine, and HCl to give the m-xylenes 12a,c,d as the major products, whereas it reacts with silver nitrate in the presence of ethanol and aniline to give the o-xylenes 11e,f as the major products.Similarly, 3-methylbenzocyclopropene (10) gives mainly m-xylenes 14a,c,d with halogens and HCl and gives p-xylenes 13e,f with silver nitrate and ethanol or aniline.Cyclopropabenzocyclobutene (15) also gives different products with halogens and silver nitrate, but in this case HCl gives the same type of product as the silver ion.The difference in electrophilic behavior of 5, 10, and 15 toward the two types of reagents is suggested to arise from attack of the silver ion (and the proton in the case of 15) on the ? electrons of the cyclopropyl ring.