7537-05-5Relevant academic research and scientific papers
Total synthesis and biological evaluation of an antifungal tricyclic o-hydroxy-p-quinone methide diterpenoid
Huang, Jinhua,Foyle, Dylan,Lin, Xiaorong,Yang, Jiong
, p. 9166 - 9173 (2013)
A convergent route has been developed to synthesize an antifungal tricyclic o-hydroxy-p-quinone methide diterpenoid and analogues. A Li/naphthalene- mediated reductive alkylation was employed for coupling β-cyclocitral and the corresponding benzyl chloride, while a BBr3-mediated one-pot bis-demethylation and intramolecular Friedel-Crafts alkylation was used to assemble the tricyclic molecular skeleton. The structure-activity relationship of the diterpenoid was assessed on the basis of antiproliferation assays of the natural product and analogues against strains of pathogenic yeasts and filamentous fungi.
A facile synthesis of functionalized catechols
Li, Chaozhong,Angelici, Robert J.
, p. 4235 - 4238 (2007/10/03)
A general route to functionalized catechols is achieved by the reaction of 3,6-di(chloromethyl)-4,5-dimethyl-catechol with various nucleophiles in the presence of a base. The reactions are proposed to occur by way of a dehydrochlorinated intermediate which undergoes Michael additions to give the catechol products.
PHOTOREACTION OF PHTHALIMIDES POSSESSING AN ORTHO-METHYLPHENYL GROUP IN THEIR N-SIDE CHAIN. SYNTHESIS OF TETRACYCLIC NITROGEN HETEROCYCLES
Machida, Minoru,Nakamura, Mayumi,Oda, Kazuaki,Takechi, Haruko,Ohno, Kosei,et al.
, p. 2683 - 2690 (2007/10/02)
Upon irradiation phthalimides (5 and 8) possesing o-methylphenyl group in their N-side chain gave mainly the tetracyclic ring systems (9 and 10).It was shown that the photocyclization occurs at ε- or ζ-position across the carbons of the benzene ring (B-ring).
