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2-(4,5-Dimethoxy-2-methyl-phenyl)-3-oxo-butyronitrile is a complex organic compound with the molecular formula C12H13NO3. It features a 2-methyl-phenyl group with two methoxy substituents at the 4 and 5 positions, attached to a 3-oxo-butyronitrile moiety. 2-(4,5-Dimethoxy-2-methyl-phenyl)-3-oxo-butyronitrile is characterized by its aromatic ring structure, which contributes to its chemical properties and potential applications. The presence of the nitrile group (-CN) and the ketone group (C=O) in the molecule suggests that it may have reactivity towards nucleophiles and could be involved in various chemical transformations. The compound's structure also implies potential applications in the synthesis of pharmaceuticals, agrochemicals, or other specialty chemicals, where its specific functional groups can be exploited for further reactions or as intermediates in larger synthetic schemes.

7537-13-5

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7537-13-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7537-13-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,3 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7537-13:
(6*7)+(5*5)+(4*3)+(3*7)+(2*1)+(1*3)=105
105 % 10 = 5
So 7537-13-5 is a valid CAS Registry Number.

7537-13-5Relevant academic research and scientific papers

8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists

Gilligan, Paul J.,He, Liqi,Clarke, Todd,Tivitmahaisoon, Parcharee,Lelas, Snjezana,Li, Yu-Wen,Heman, Karen,Fitzgerald, Lawrence,Miller, Keith,Zhang, Ge,Marshall, Anne,Krause, Carol,McElroy, John,Ward, Kathyrn,Shen, Helen,Wong, Harvey,Grossman, Scott,Nemeth, Gregory,Zaczek, Robert,Arneric, Stephen P.,Hartig, Paul,Robertson, David W.,Trainor, George

experimental part, p. 3073 - 3083 (2010/01/16)

This report describes the syntheses and structure-activity relationships of 8-(4-methoxyphenyl)pyrazolo-[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF1) receptor antagonists. CRF1 receptor antagonists may be potential anxiolytic or antidepressant drugs. This research culminated in the discovery of analogue 12-3, which is a potent, selective CRF1 antagonist (hCRF1 IC50 ) 4.7 ± 2.0 nM) with weak affinity for the CRF-binding protein and biogenic amine receptors. This compound also has a good pharmacokinetic profile in dogs. Analogue 12-3 is orally effective in two rat models of anxiety: the defensive withdrawal (situational anxiety) model and the elevated plus maze test. Analogue 12-3 has been advanced to clinical trials.

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