75391-05-8

Upstream product

• 1046862-49-0 (E)-7-(4-nitrophenoxy)-7-phenylhept-4-en-3-one 
• 14371-10-9 (E)-3-phenylpropenal 
• 78-93-3 butanone 
• 70960-88-2 trimethyl ((1E,3E)-4-phenylbuta-1,3-dien-1-yl)silane 
• 123-62-6 propionic acid anhydride 
• 1629-58-9 4-penten-3-one 
• 536-74-3 phenylacetylene 
• 89567-74-8 (3E)-4-phenyl-1-trimethylsilyl-1,3-butadiene 
• 103-64-0 bromostyrene 
• 245761-92-6 5-diethylphosphonylmethyl-3-ethyl-2-isoxazoline 

Relevant academic research and scientific papers

Palladium-catalysed atom-economical synthesis of conjugated dienals from terminal acetylenes and acrolein

Conjugated (E,E)-dienals are versatile synthetic intermediates owing to their trifunctional, electrophilic nature and the prevalence of the (E,E)-diene in a wide range of functional molecules. It is shown herein that (E,E)-dienals can be readily prepared

Iridium-catalysed desilylative acylation of 1-alkenylsilanes

We report the iridium-catalysed desilylative acylation of styryl and dienyl silanes by acid anhydrides to afford (E)-α,β-unsaturated ketones. The [{Ir(μ-Cl)(cod)}2] catalyst is the first non-rhodium complex successfully applied for this type of

Regio- and Enantioselective Copper-Catalyzed 1,4-Conjugate Addition of Trimethylaluminium to Linear α,β,γ,δ-Unsaturated Alkyl Ketones

A regio- and enantioselective copper-catalyzed 1,4-conjugate addition of trimethylaluminium to linear δ-aryl-substituted α,β,γ,δ-unsaturated alkyl ketones was developed. A series of γ,δ-unsaturated alkyl ketones were obtained in good yields with high regio- and enantioselectivity (up to 88% ee and 96:4 dr). Expansion of the reaction scope to substrates containing aromatic heterocycles also afforded good yields and enantioselectivities (up to 91% ee) with very high regioselectivities, exclusively providing the single 1,4-products. (Figure presented.).

Ruthenium-Catalyzed Silylation of 1,3-Butadienes with Vinylsilanes

A novel method for the synthesis of 1-silyl-substituted 1,3-butadienes, based on [RuHCl(CO)(PCy3)2]-catalyzed silylative coupling of terminal (E)-1,3-dienes with vinylsilanes, is reported. The reaction provides a facile and straightf

Palladium-tetraphosphine complex catalysed heck reaction of vinyl bromides with alkenes: A powerful access to conjugated dienes

A wide variety of 1,3-dienes have been prepared by the Heck vinylation of vinyl bromides using [Pd(η3-C3H5)Cl] 2/cis,cis,cis-1,2,3,4-tetrakis[(diphenylphosphino)methyl] cyclopentane (Tedicyp) as the catalyst precursor. Both α- and β-substituted vinyl bromides undergo the Heck reaction with functionalised alkenes such as acrylates, enones, styrenes or a vinyl sulfone, and also with nonfunctionalised alkenes such as dec-1-ene, leading stereoselectively, in most cases, to the corresponding E- or E,E-1,3-dienes in good yields. Furthermore, this catalyst can be used at low loading for several reactions. Georg Thieme Verlag Stuttgart.

Tandem olefin metathesis-elimination reactions. A new route to doubly unsaturated carbonyl derivatives

Cross-metathesis between an activated olefin and an ethereal derivative of homoallylic alcohols leads to products that are subject to facile elimination resulting in α,β,γ,δ-unsaturated esters, ketones, acids, and aldehydes in high yields.

Lithium Iodide-promoted Aldol Condensation Reactions

Anhydrous lithium iodide in ether, tetrahydrofuran, or benzene is an effective reagent for the formation of α,β-unsaturated ketones by condensation of alkyl ketones with enolisable and non-enolisable aldehydes; in the presence of trimethylchlorosilane-triethylamine enone formation is suppressed and high yields of 1,3-hydroxyketones are obtained as their trimethylsilyl ether derivatives.