75391-22-9Relevant academic research and scientific papers
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jourdan, Jean-Pierre,Since, Marc,El Kihel, La?la,Lecoutey, Cédric,Corvaisier, Sophie,Legay, Rémi,Sopkova-De Oliveira Santos, Jana,Cresteil, Thierry,Malzert-Fréon, Aurélie,Rochais, Christophe,Dallemagne, Patrick
, p. 365 - 379 (2016/04/19)
This work describes the synthesis and the biological evaluation of novel benzylidenephenylpyrrolizinones as potential antioxidant, metal chelating or amyloid β (βA) aggregation inhibitors. Some derivatives exhibited interesting results in regard to several of the performed evaluations and appear as valuable Multi-Target Directed Ligands with potential therapeutic interest in Alzheimer's disease. Among them, compound 29 particularly appears as a valuable radical and NO scavenger, a Cu(II) and Fe(II) chelating agent and exhibits moderate βA aggregation inhibition properties. These activities, associated to a good predictive bioavailability and a lack of cytotoxicity, design it as a promising hit for further in vivo investigation.
New aromatase inhibitors. Synthesis and biological activity of aryl- substituted pyrrolizine and indolizine derivatives
Sonnet, Pascal,Dallemagne, Patrick,Guillon, Jean,Enguehard, Cecile,Stiebing, Silvia,Tanguy, Julien,Bureau, Ronan,Rault, Sylvain,Auvray, Pierrick,Moslemi, Safa,Sourdaine, Pascal,Seralini, Gilles-Eric
, p. 945 - 955 (2007/10/03)
We report herein the design and the synthesis of some aryl-substituted pyrrolizine and indolizine derivatives, on the basis of a hypothetical pharmacophore structure designed to fit the catalytic site of the human cytochrome P450 aromatase. The in vitro b
An Efficient Synthesis of New Phenylpyrrolizine and Phenylpyrrolopyrazine Derivatives
Tembo, Olivier Norbert,Dallemagne, Patrick,Rault, Sylvain,Robba, Max
, p. 2129 - 2138 (2007/10/02)
Synthesis of new 3-phenyl-2,3-dihydro-1H-pyrrolizine derivatives is achieved starting from 3-amino-3-phenylpropionic acid via an iminium salt.The reactivity of this system is studied and the new 4-phenyl-1,2,3,4-tetrahydropyrrolopyrazin-1-one deriv
