154284-02-3Relevant academic research and scientific papers
Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43
Guillon,Boulouard,Lelong,Dallemagne,Rault,Jarry
, p. 1561 - 1568 (2007/10/03)
The 2-aryl-3-indoleacetamides FGIN-1-27 and FGIN-1-43 have already been characterized in-vitro as potent and specific ligands for the mitochondrial DBI receptor. This affinity was associated with psychotropic properties in several rodent behavioural tasks (in particular anxiolytic action) via enhancement of GABA transmission through neurosteroid production. The synthesis of new 3-aryl-3-pyrrol-1-ylpropanamides 1a-i, analogues of FGIN-1-27 and FGIN-1-43, is described in four steps starting from the corresponding arylaldehydes. Preliminary evaluation of these compounds in behavioural studies (spontaneous locomotor activity and anxiolytic activity) in mice was also undertaken.
Synthesis and CNS activity of new 3-amino-3-arylpropionic acid derivatives
Renault,Guillon,Huard,Miel,Stiebing,Le Bourn,Boulouard,Dallemagne,Rault
, p. 217 - 223 (2007/10/03)
The synthesis of new analogues of methylphenidate and modafinil, derived from 3-amino-3-arylpropionic acids, is described. Central pharmacological properties were studied in mice.
An Efficient Synthesis of New Phenylpyrrolizine and Phenylpyrrolopyrazine Derivatives
Tembo, Olivier Norbert,Dallemagne, Patrick,Rault, Sylvain,Robba, Max
, p. 2129 - 2138 (2007/10/02)
Synthesis of new 3-phenyl-2,3-dihydro-1H-pyrrolizine derivatives is achieved starting from 3-amino-3-phenylpropionic acid via an iminium salt.The reactivity of this system is studied and the new 4-phenyl-1,2,3,4-tetrahydropyrrolopyrazin-1-one deriv
