754145-88-5

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 78-96-6 3-amino-2-propanol 

Downstream Products

• 856978-80-8 1-{[(4-methoxyphenyl)methyl]amino}propan-2-ol 
• 1375744-89-0 phenyl N-{[(2-hydroxypropyl)[(4-methoxyphenyl)methyl]carbamoyl]methyl}-N-methylcarbamate 
• 1375744-69-6 phenyl N-({[(4-methoxyphenyl)methyl](2-oxopropyl)carbamoyl}methyl)-N-methylcarbamate 
• 1375744-68-5 3-acetyl-4-[(4-methoxyphenyl)methyl]-1-methylpiperazine-2,5-dione 

Relevant academic research and scientific papers

A Dieckmann cyclization route to piperazine-2,5-diones

Piperazine-2,5-diones are formed by Dieckmann cyclization (NaH, THF) of substructures of the type CH2-N(R)C(O)CH2N(R′) CO2Ph in which the terminal methylene (CH2) that is adjacent to nitrogen closes onto the carbonyl group of the phenyl carbamate unit at the other end of the chain. R and R′ are alkyl groups, and the terminal methylene is activated by a ketone carbonyl, a nitrile, an ester, or a phosphoryl group. The starting materials are assembled by standard acylation and oxidation processes, starting from a β-(alkylamino)alcohol, an (alkylamino)acetonitrile, an (alkylamino) ester, or an (alkylamino)methyl phosphonate.