75416-53-4Relevant academic research and scientific papers
INTRAMOLECULAR FRIEDEL-CRAFTS ALKYLATIONS. II. AN EFFICIENT SYNTHESIS OF BIOLOGICALLY ACTIVE 1,2,3,4-TETRAHYDROISOQUINOLINES
Mendelson, W. L.,Spainhour, C. B.,Jones, S. S.,Lam, B. L.,Wert, K. L.
, p. 1393 - 1396 (1980)
A new synthesis of tetrahydroisoquinolines bearing electron withdrawing groups is presented.The scope and mechanism of the reaction are discussed.Many of these tetrahydroisoquinolines are potent inhibitors of the enzyme PNMT.
