754190-30-2Relevant academic research and scientific papers
Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors
Gomtsyan, Arthur,Didomenico, Stanley,Lee, Chih-Hung,Stewart, Andrew O.,Bhagwat, Shripad S.,Kowaluk, Elizabeth A.,Jarvis, Michael F.
, p. 4165 - 4168 (2007/10/03)
Three new approaches have been tested to modify existing pyridopyrimidine and alkynylpyrimidine classes of nonnucleoside adenosine kinase inhibitors 2 and 3. 4-Amino-substituted pteridines 8a-e were generally less active than corresponding 5- and 6-substituted pyridopyrimidines 2. Pyrazolopyrimidine 13c with IC50=7.5nM was superior to its open chain alkynylpyrimidine analog 13g (IC50=22nM) while pyrrolopyrimidines such as 17a were inactive.
