109574-98-3

Basic information

• Product Name: 4,6-Dichloro-5-(α-hydroxybenzyl)-pyrimidine
• Synonyms: 4,6-Dichloro-5-(α-hydroxybenzyl)-pyrimidine
• CAS NO: 109574-98-3
• Molecular Weight: 255.103
• Mol File: 109574-98-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4,6-Dichloro-5-(α-hydroxybenzyl)-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dichloro-5-(α-hydroxybenzyl)-pyrimidine(109574-98-3)
• EPA Substance Registry System: 4,6-Dichloro-5-(α-hydroxybenzyl)-pyrimidine(109574-98-3)

Safety Data

• Hazardous Substances Data: 109574-98-3(Hazardous Substances Data)

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 100-52-7 benzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 

Downstream Products

• 960298-98-0 (4-(benzyloxy)-6-chloropyrimidin-5-yl)(phenyl)methanol 
• 109575-12-4 4,6-Diamino-5-benzoylpyrimidine 
• 109575-06-6 4-Amino-5-benzoyl-6-chloropyrimidine 
• 109575-04-4 (4,6-dichloropyrimidin-5-yl)(phenyl)methanone 
• 754190-30-2 [4-chloro-6-(6-dimethylamino-pyridin-3-ylethynyl)-pyrimidin-5-yl]-phenyl-methanone 

Relevant articles and documents

QUINOLINE COMPOUNDS AND METHODS OF USE

Compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [ Formula I]

Synthesis of 4-Amino-3-pyridinyl and 4-Amino-5-pyrimidinyl Aryl Ketones and Related Compounds via an ortho-Lithiation Reaction

4-Chloropyridine and 4,6-dichloropyrimidine react regioselectively with lithium diisopropylamide to give 4-chloro-3-lithiopyridine and 4,6-dichloro-5-lithiopyrimidine, respectively.These intermediates react with benzaldehydes to give (4-chloro-3-pyridinyl