754208-00-9Relevant academic research and scientific papers
Simple and efficient synthetic routes to s-triazinyl dithiocarbamate derivatives: 2,4-Diarylamino-6-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-s-triazines and 2,4-bis-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-6-arylamino-s-triazines
Desai,Ravat,Shah
, p. 367 - 373 (2007/10/03)
Compounds 2,4-diarylamino-6-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-s-triazines 4a-f and 2,4-bis-[N-(4′ -ethoxyphenyl)dithiocarbamoyl]-6-arylamino-s-triazines 7a-f have been synthesized by two different methods. In the first method (A) of preparation, 2,4,6-trichloro-s-triazine 1 is condensed with N-(4-ethoxyphenyl)ammoniumdithiocarbamate to afford 3 or 6 followed by the reaction with arylamines to afford 4a-f or 7a-f. In the second method (B) of preparation, 1 is condensed with arylamines to yield 2a-f or 5a-f followed by the action of N-(4-ethoxyphenyl)ammoniumdithiocarbamates to yield 4a-f or 7a-f. The constitutions of newly synthesised compounds 4a-f and 7a-f have been established on the basis of elemental analyses, IR and PMR spectral data. Antimicrobial activity of compounds 4a-f and 7a-f are performed by using cup-plate method against gram-positive bacteria, gram-negative bacteria and antifungal fungi. All the synthesised compounds have shown significant antimicrobial activity.
