754214-54-5

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-;5-BROMO-1-(TERT-BUTYLDIMETHYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE
• CAS NO: 754214-54-5
• Molecular Formula: C₁₃H₁₉BrN₂Si
• Molecular Weight: 311.29
• Mol File: 754214-54-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 286.3°C at 760 mmHg
• Flash Point: 127°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.00266mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-(754214-54-5)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-(754214-54-5)

Safety Data

• Hazardous Substances Data: 754214-54-5(Hazardous Substances Data)

Usage

Brominated pyrrolopyridine compound

This molecule contains a bromine atom and a pyrrolopyridine core.

t-Butyl dimethylsilyl (TBDMS) protecting group

A protective group attached to the molecule to prevent unwanted reactions during synthesis.

Intermediate in the synthesis of pharmaceuticals and organic compounds

This compound is used as a starting material or building block in the synthesis of other molecules.

Potent biological activities

The compound has strong effects on biological systems, making it useful in medicinal chemistry.

Used in the development of new drug candidates

Researchers use this compound to create potential new drugs.

Structure consists of a pyrrolopyridine core with a bromine substituent at position 5

The compound has a specific arrangement of atoms, with a bromine atom attached to the fifth position of the pyrrolopyridine core.

TBDMS group attached to the nitrogen atom

The protective group is attached to the nitrogen atom in the molecule.

Important for use in research and development of new drugs and organic compounds

This compound is valuable for creating new molecules and advancing scientific knowledge.

InChI:InChI=1/C13H19BrN2Si/c1-13(2,3)17(4,5)16-7-6-10-8-11(14)9-15-12(10)16/h6-9H,1-5H3

Upstream product

• 271-63-6 7-Azaindole 
• 10592-27-5 7-azaindoline 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 183208-36-8 5-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 397842-89-6 5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1312017-88-1 1-benzenesulfonyl-5-vinyl-1H-pyrrolo[2,3-b]pyridine 
• 1312017-98-3 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclohexyl-ethanol 
• 1312018-04-4 5-allyl-1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine 
• 1312018-13-5 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-ethanol 
• 1312018-29-3 1-(1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-(tetrahydro-furan-2-yl)-ethanol 
• 1312019-37-6 (1-benzenesulfonyl-5-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-methanol 
• 1001070-33-2 1-(benzenesulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 1312016-63-9 5-methoxy-2-[2-(tetrahydro-pyran-4-yl)-1(R)-(4-trifluoromethyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312021-10-5 5-methoxy-2-[2-(tetrahydro-pyran-4-yl)-1(S)-(4-trifluoromethyl-phenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridine 
• 1312016-59-3 2-[1(R)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yl)-ethyl]-5-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 1312021-09-2 2-[1(S)-(4-methanesulfonyl-phenyl)-2-(tetrahydro-pyran-4-yl)-ethyl]-5-methoxy-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

AZAINDOLE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

SYNTHESIS

The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.