754226-34-1

Usage

Uses

Used in Pharmaceutical Research:
3-Fluoro-4-methoxyphenylboronic acid, pinacol ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and stability, due to the presence of fluorine atoms, make it a valuable component in the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Fluoro-4-methoxyphenylboronic acid, pinacol ester is used as a building block for the creation of complex organic molecules. Its ability to form reversible covalent bonds through the boronic acid portion is particularly beneficial in coupling reactions, such as the Suzuki-Miyaura cross-coupling, which aids in the formation of carbon-carbon bonds.
Used in Medicinal Chemistry:
3-Fluoro-4-methoxyphenylboronic acid, pinacol ester is employed as a reagent in medicinal chemistry for the synthesis of bioactive molecules. Its unique properties, including the contribution of fluorine atoms to its stability and reactivity, make it an essential tool in the development of new therapeutic agents.

Upstream product

• 2357-52-0 3-fluoro-4-methoxyphenyl bromide 
• 73183-34-3 bis(pinacol)diborane 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 149507-26-6 3-fluoro-4-methoxy-phenylboronic acid 

Relevant academic research and scientific papers

NOVEL IMIDAZOPYRAZINE DERIVATIVES

The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein Rx and R3 to R5 are as described herein (formula (I)) or pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF AS PI3K INHIBITOR

The present invention discloses a series of pyrazolopyrimidine derivatives and use thereof in preparing a medicament for treating a disease related to PI3K, and in particular, discloses a derivative compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof.

Visible Light-Induced Borylation of C-O, C-N, and C-X Bonds

Boronic acids are centrally important functional motifs and synthetic precursors. Visible light-induced borylation may provide access to structurally diverse boronates, but a broadly efficient photocatalytic borylation method that can effect borylation of a wide range of substrates, including strong C-O bonds, remains elusive. Herein, we report a general, metal-free visible light-induced photocatalytic borylation platform that enables borylation of electron-rich derivatives of phenols and anilines, chloroarenes, as well as other haloarenes. The reaction exhibits excellent functional group tolerance, as demonstrated by the borylation of a range of structurally complex substrates. Remarkably, the reaction is catalyzed by phenothiazine, a simple organic photocatalyst with MW 200 that mediates the previously unachievable visible light-induced single electron reduction of phenol derivatives with reduction potentials as negative as approximately - 3 V versus SCE by a proton-coupled electron transfer mechanism. Mechanistic studies point to the crucial role of the photocatalyst-base interaction.

Pd II -Porphyrin Complexes - The First Use as Safer and Efficient Catalysts for Miyaura Borylation

We have developed a simple and convenient procedure for the preparation of pinacol arylboronates from aryl/heteroaryl bromides and bis(pinacolato)diborane using a Pd II -porphyrin complex as a catalyst. Seven different Pd II -porphyrin complexes (Pd II -T m HPP, Pd II -T m CPP, Pd II -TPP, Pd II -TST p SPP, Pd II -T p CPP, Pd II -T p TP, and Pd II -T p AP) have been synthesized and investigated for their catalytic influence in the Miyaura borylation.

Enantioselective installation of adjacent tertiary benzylic stereocentres using lithiation-borylation-protodeboronation methodology. Application to the synthesis of bifluranol and fluorohexestrol

1,2-Diaryl ethanes bearing 1,2-stereogenic centres show interesting biological activity but their stereocontrolled synthesis has not been reported forcing a reliance of methods involving diastereomer and enantiomer separation. We have found that this clas