2357-52-0Relevant articles and documents
The Synthesis and Transition Temperatures of Benzoate Ester Derivatives of 2-Fluoro-4-hydroxy- and 3-Fluoro-4-hydroxybenzonitriles
Kelly, Stephen M.
, p. 1572 - 1579 (1984)
The synthesis and the liquid-crystal temperatures of sixty 4-cyano-2-flurophenyl and 4-cyano-3-fluorophenyl 4-substituted benzoates are described.The nematic-isotropic liquid transition temperatures of most of these novel esters are only marginally lower than those of the corresponding esters containing an H-atom in place of the F-substituent.In several instances, the clearing points of the F-substituted-phenyl esters are higher than those of the non-substituted-phenyl esters.The nematic ranges of several new esters are markedly broader than those of the analogous non-F-susbstituted-phenyl esters.
Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol
Tang, Ren-Jin,Milcent, Thierry,Crousse, Benoit
, p. 930 - 938 (2018/01/28)
Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.
Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition
Li, Yi-Xian,Iwaki, Ren,Kato, Atsushi,Jia, Yue-Mei,Fleet, George W. J.,Zhao, Xuan,Xiao, Min,Yu, Chu-Yi
, p. 1429 - 1438 (2016/03/16)
Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities. Fluorinated derivatives of radicamine A and B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies revealed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom.