75436-40-7

Usage

Uses

Used in Organic Synthesis:
5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester is utilized as a key building block in organic synthesis for the creation of diverse organic compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester is employed as a starting material for the development of new drugs. Its potential biological activities are of interest for exploring its therapeutic applications, particularly in the discovery of novel compounds with medicinal properties.
Used in Chemical Research:
5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester is also used in chemical research to study its chemical properties and reactivity. This research is crucial for understanding how the compound can be manipulated and applied in various chemical processes, potentially leading to new methods and techniques in synthetic chemistry.
Overall, 5-Formyl-2H-pyrazole-3-carboxylic acid methyl ester is a multifaceted compound with applications spanning across organic synthesis, pharmaceutical development, and chemical research, making it a subject of significant interest for scientists and researchers in related fields.

Upstream product

• 75436-38-3 methyl 5-[bis(methyloxy)methyl]-1H-pyrazole-3-carboxylate 
• 75436-38-3 methyl 3-(dimethoxymethyl)-1H-pyrazole-5-carboxylate 

Downstream Products

• 1254966-55-6 5-{(Z)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-54-5 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2H-pyrazole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2)

3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein, a series of isoquinolones with an imidazolylmethyl or a pyrazolylmethyl group at the 2-position were designed based on X-ray crystallographic analysis of the complex between the isoquinolone compound and JNK3, as wells as the relationship between compound lipophilicity (log D) and activity in a cell-based assay. The compounds prepared showed potent JNK1 inhibitory activities in a cell-based assay. Among them the isoquinolone derivative possessing 5-[(cyclopropylamino)carbonyl]-1-methyl-1H-pyrazole (16e) exhibited significant anti-hypertrophic activity at doses of more than 1 mg/kg (po) in a pressure-overload model.

Le dimethylacetal du diazoacetaldehyde: une nouvelle voie d'acces aux formylcyclopropanes et aux formyl pyrazoles

Formylcyclopropanes are conveniently obtained through reaction of diazoacetaldehyde dimethylacetal 1 even with olefins which are not highly electrophilic (styrene, cinnamaldehydeacetal, cyanocyclopentene for instance).Only 3,5-disubstituted formylpyrazole

LE DIMETHYL ACETAL DU DIAZOACETALDEHYDE : UNENOUVELLE VOIE D'ACCES AUX CYCLOPROPANES ALDEHYDES ET AUX FORMYL PYRAZOLES.

Diazoacetaldehyde dimethylacetal 1 is a readily accessible and highly reactive 1,3 dipole.Starting from 1, both electrophilic cyclopropanes with an extra aldehyde function and formyl pyrazoles are prepared in high yields.