75438-54-9

Basic information

• Product Name: 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE
• Synonyms: 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE;4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLINE-2-YL)-AMINOPYRIDINE;1-Acetyl-2-[(4,6-dichloro-2-methylpyrimidin-5-yl)amino]-4,5-dihydro-1H-imidazole, 5-[(1-Acetyl-4,5-dihydro-1H-imidazol-2-yl)amino]-4,6-dichloro-2-methylpyrimidine;Ethanone,1-[2-[(4,6-dichloro-2-Methyl-5-pyriMidinyl)aMino]-4,5-dihydro-1H-iMidazol-1-yl]-;1-Acetyl-N-(4,6-dichloro-2-methyl-5-pyrimidinyl)-4,5-dihydro-1H-imidazol-2-amine;1-(2-((4,6-Dichloro-2-MethylpyriMidin-5-yl)aMino)-4,5-dihydro-1H-iMidazol-1-yl)ethanone
• CAS NO: 75438-54-9
• Molecular Formula: C₁₀H₁₁Cl₂N₅O
• Molecular Weight: 288.13
• EINECS: 200-258-5
• Mol File: 75438-54-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 394.7 °C at 760 mmHg
• Flash Point: 192.5 °C
• Appearance: /
• Density: 1.59±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 0.41±0.20(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE(75438-54-9)
• EPA Substance Registry System: 4,6-DICHLORO-2-METHYL-5-(1-ACETYL-2-IMIDAZOLIN-2-YL)-AMINOPYRIDINE(75438-54-9)

Safety Data

• Hazardous Substances Data: 75438-54-9(Hazardous Substances Data)

Usage

Uses

4,6-Dichloro-2-methyl-5-((1-acetyl-2-imidazolin-2-yl)amino)pyrimidine is an intermediate in the synthesis of Moxonidine-13C,d3 (M745803), a labelled antihypertensive agent.

Upstream product

• 39906-04-2 5-amino-4,6-dichloro-2-methylpyrimidine 
• 5391-39-9 1-acetylimidazolidin-2-one 
• 438000-58-9 1-[1-((4,6-dichloro-2-methyl-pyrimidin-5-yl)imino)-ethyl]-imidazolidin-2-one 

Downstream Products

• 75438-57-2 moxonidine 
• 75438-55-0 4-chloro-2-methyl-6-methylthio-5-(2-imidazolin-2-yl)-aminopyrimidine 
• 75438-59-4 4,6-di-methylthio-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine 
• 75438-91-4 4-chloro-6-ethoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine 
• 1033401-62-5 1-[1-[(4-chloro-2-methyl-6-methoxy-pyrimidin-5-yl)imino]ethyl]-imidazolidin-2-one 
• 352457-35-3 4,6-dichloro-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine 
• 75439-01-9 4,6-dimethoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine 
• 438000-58-9 1-[1-((4,6-dichloro-2-methyl-pyrimidin-5-yl)imino)-ethyl]-imidazolidin-2-one 

Relevant articles and documents

Process for the preparation of moxonidine

The present invention provides an improved process for the preparation of 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)aminopyrimidine. The present invention also provides an improved process for the preparation of moxonidine. The present invention further provides a process for the purification of moxonidine.

Substituted aminopyrimidines

The present invention is directed to certain aminopyrimidines of the general formula STR1 wherein R1, R2, and R3 are hydrogen, halogen, alkoxy, alkylthio, or alkyl having 1 to 4 carbon atoms, or cycloalkyl having 3 to 5 carbon atoms and R4 is hydrogen or an aliphatic or aromatic acyl group, as well as physiologically compatible acid addition salts thereof. Compounds of the present invention are useful as blood pressure lowering agents and in the treatment of glaucoma.