75444-80-3

Basic information

• Product Name: Benzo[b]thiophene-2-acetonitrile
• CAS NO: 75444-80-3
• Molecular Formula: C10H7NS
• Molecular Weight: 173.238
• Mol File: 75444-80-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzo[b]thiophene-2-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Benzo[b]thiophene-2-acetonitrile(75444-80-3)
• EPA Substance Registry System: Benzo[b]thiophene-2-acetonitrile(75444-80-3)

Safety Data

• Hazardous Substances Data: 75444-80-3(Hazardous Substances Data)

Usage

General Description

Benzo[b]thiophene-2-acetonitrile is a chemical compound with the molecular formula C11H7NS. It is a yellow to brown solid that is used as a building block in the synthesis of pharmaceuticals and agrochemicals. Benzo[b]thiophene-2-acetonitrile is of interest to chemists and researchers due to its potential biological and industrial applications. Its structure contains a benzo[b]thiophene ring and an acetonitrile functional group, making it valuable for the development of new drug candidates and other organic compounds. However, it is important to handle this compound with care as it may be hazardous if not managed properly.

Upstream product

• 148961-88-0 2-(tributylstannyl)benzothiophene 
• 123-91-1 1,4-dioxane 
• 17890-56-1 benzothiophene-2-methanol 
• 2076-88-2 2-chloromethylbenzo[b]thiophene 
• 95-15-8 Benzo[b]thiophene 
• 6314-28-9 benzo[b]thiophene-2-carboxylic acid 
• 1195-14-8 2-Methylbenzothiophene 
• 825-44-5 benzothiophene-1,1-dioxide 
• 10133-20-7 2-bromomethylbenzo[b]thiophene 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 

Relevant articles and documents

Two-step cyanomethylation protocol: Convenient access to functionalized aryl- and heteroarylacetonitriles

A two-step protocol has been developed for the introduction of cyanomethylene groups to metalated aromatics through the intermediacy of substituted isoxazoles. A palladium-mediated cross-coupling reaction was used to introduce the isoxazole unit, followed by release of the cyanomethylene function under thermal or microwave-assisted conditions. The intermediate isoxazoles were shown to be amenable to further functionalization prior to deprotection of the sensitive cyanomethylene motif, allowing access to a wide range of aryl- and heteroaryl-substituted acetonitrile building blocks.

Substituted 4-arylmethylene-2-imino-2,3-dihydrothiazoles and derivatives and their pharmaceutical use

Compounds of Formula I including pharmaceutically acceptable salts thereof in the form of individual enantiomers, racemates, or other mixtures of enantiomers, in which Ar is phenyl, naphthyl or benzo[b]thiophenyl, each of which may be optionally substituted; R1and R2, which may be the same or different, independently are a) H, b) an alkyl group containing 1 to 6 carbon atoms, c) an alkenyl group containing 3 to 6 carbon atoms, d) a cycloalkyl group containing 3 to 7 carbon atoms, e) a cycloalkylmethyl group in which the ring contains 3 to 7 carbon atoms, f) an aryl or heteroaryl group optionally substituted g) an arylalkyl or heteroarylalkyl group each optionally substituted; or R1and R2form an alkylene chain optionally substituted by one or more alkyl groups each containing 1 to 3 carbon atoms, such that, together with the atoms to which they are attached, they form a 5 or 6 membered ring; R3is a) H, b) an aryl or heteroaryl group each optionally substituted c) an optionally substituted arylmethyl group; or d) an alkoxyalkyl group containing 3 to 6 carbon atoms; and R4and R5, which may be the same or different, independently are an alkyl group containing 1 to 3 carbon atoms, or R4and R5together with the atom to which they are attached form a cycloalkyl ring containing 3 to 6 carbon atoms; processes to prepare such compounds; compositions containing such compounds and their use in the treatment of depression, anxiety, Parkinson's disease, obesity, cognitive disorders, seizures, neurological disorders and as neuroprotective agents; are described.

BECKMANN FISSION OF SOME FUSED CYCLOBUTANONES: A NEW ENTRY INTO INDOLE-2-ACETONITRILES AND BENZOTHIOPHENE-2-ACETONITRILE

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