75452-57-2

Basic information

• Product Name: methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate
• Synonyms: methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate
• CAS NO: 75452-57-2
• Molecular Weight: 321.76
• Mol File: 75452-57-2.mol

Chemical Properties

• CAS DataBase Reference: methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate(75452-57-2)
• EPA Substance Registry System: methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate(75452-57-2)

Safety Data

• Hazardous Substances Data: 75452-57-2(Hazardous Substances Data)

Upstream product

• 69049-54-3 1-(4-Acetylamino-2-hydroxy-3-propylphenyl)ethanone 
• 69069-03-0 1-(4-Acetylamino-3-(prop-2-enyl)-2-hydroxyphenyl)ethanone 
• 75452-54-9 1-(4-amino-2-hydroxy-3-propylphenyl)ethanone 
• 98331-40-9 (Z)-dimethyl 2-<(4-acetyl-3-hydroxy-2-propylphenyl)-amino>butene-1,4-dioate 
• 7298-72-8 4-Acetamido-2-allyloxyacetophenone 
• 40547-58-8 N-(4-acetyl-3-hydroxyphenyl)acetamide 
• 75452-56-1 methyl 6-acetyl-1,4-dihydro-7-hydroxy-4-oxo-8-propylquinoline-2-carboxylate 

Downstream Products

• 75453-60-0 Methyl 6-acetyl-7-hydroxy-4-phenylthio-8-propyl-quinoline-2-carboxylate 
• 75453-28-0 dissodium 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quinoline-2,8-dicarboxylate 
• 75453-27-9 diethyl 4-oxo-6-phenoxy-10-propyl-4H-pyrano<3,2-g>quilnoline-2,8-dicarboxylate 
• 75453-22-4 Methyl 6-acetyl-7-hydroxy-8-propylquinoline-2-carboxylate 
• 75453-26-8 methyl 6-acetyl-7-hydroxy-4-phenoxy-8-propylquinoline-2-carboxylate 

Relevant articles and documents

New Antiallergic Pyranoquinoline-2,8-dicarboxylic Acids with Potential for the Topical Treatment of Asthma

A nimber of antiallergic pyranoquinolinedicarboxylic acid derivatives with potential for the topical treatment of asthma have been synthesized.All the compounds have been evaluated against rat passive cutaneous anaphylaxis and in a dog hypotension screen.This is the first detailed description of the application of the latter screen for the identification of antiallergic agents.Two compounds, disodium 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyranoquinoline-2,8-dicarboxylate (86) and disodium 6-(methylamino)-4-oxo-10-propyl-4H-pyranoquinoline-2,8-dicarboxylate (72), were selected and further evaluated for their ability to induce phosphorylation of a 78000 molecular weight protein associated with the rat peritoneal mast cell.Their ability to inhibit histamine release from these cells and from a mucosal mast cell preparation has also been evaluated.These compounds, nedocromil sodium (TILADE 86) and minocromil (the free acid of 72), are at present undergoing therapeutic evaluation.The rationale for the screening procedure and the relevance of the second carboxylic acid function of these dibasic acids to receptor binding are discussed.

Pyranoquinolinones and analogs thereof

There are described compounds of formula I, STR1 in which an adjacent pair of R5, R6, R7 and R8 form a chain --CZC(G1)=(G2)--Z--, R4, R9 and the remainder of R5/

Anti-allergic mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid

There is described the mono salt of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]-quinoline-2,8-dicarboxylic acid with a strongly basic cation. There is also described an aqueous solution of 6-methylamino-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid the solution being at a pH of from 4 to 8. The salts and solutions are useful as pharmaceuticals, e.g. in the treatment of allergies.