75459-97-1Relevant academic research and scientific papers
Molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael addition reaction: Efficient and mild conditions for the synthesis of 3,3-disubstituted oxindoles with an all carbon quaternary center
Guo, Yi-Lin,Li, Yu-Hsun,Chang, Hsuan-Hao,Kuo, Ting-Shen,Han, Jeng-Liang
, p. 74683 - 74690 (2016)
A one-pot, molecular sieve mediated sequential Knoevenagel condensation/decarboxylative Michael addition reaction has been developed. We discovered that the molecular sieves not only promoted the Knoevenagel condensation of isatins and malononitrile to generate isatylidene malononitriles, but also promoted the later decarboxylative Michael addition reactions of β-ketoacids and malonic acid half thioesters (MAHTs) with isatylidene malononitriles. This protocol provides a mild and efficient method for the preparation of 3,3-disubstituted oxindoles with an all carbon quaternary center in high yields.
Grinding assisted, column chromatography free decarboxylative carbon-carbon bond formation: Greener synthesis of 3, 3-disubstituted oxindoles
Kaur, Jasneet,Kumari, Anita,Chimni, Swapandeep Singh
, p. 802 - 808 (2017)
The decarboxylative carbon-carbon bond formation reaction of β-ketoacid derivatives with isatylidene malononitrile derivatives catalyzed by DBU afford adducts in excellent yield. The desired product can be easily isolated using simple filtration method without performing any column chromatography. The decarboxylative adduct was further subjected to reductive-cyclization to obtain biologically important spirooxindoles in 89% yield.
Spiro Heterocyclic Compounds. IV. Synthesis of Spiro and Spiro Compounds
Higashiyama, Kimio,Otamasu, Hirotaka
, p. 1540 - 1545 (2007/10/02)
The Michael reaction of 3-(carboethoxy-cyano)methyleneoxindole (Ia) or 3-dicyanomethyleneoxindole (Ib) with active methyl groups, e.g., acetophenone and acetone, afforded, the corresponding normal Michael adducts (IIa-c).The reduction of IIa with NaBH4 ga
