75470-78-9

Upstream product

• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 123-11-5 4-methoxy-benzaldehyde 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 85516-21-8 3-<1,2-dibromo-2-(p-methoxyphenyl)ethyl>-2(1H)-quinoxalinone 
• 1253932-75-0 6-chloro-N-[3-(2-(4-methoxyphenyl)ethenyl)quinoxalin-2(1H)-ylidene]-1,3-benzothiazol-2-amine 

Relevant academic research and scientific papers

Small molecule compound bonded with alpha-synuclein aggregate, and preparation method and application thereof

The invention belongs to the technical field of medicine, and relates to a compound capable of being bonded with alpha-synuclein aggregate, and a preparation method and application thereof. The structural general formula of the compound is shown in the formula I, wherein m is a positive integer selected from 1 to 3, R1 is respectively selected from phenyl, substituted phenyl, naphthyl, biphenyl, 5-6-membered aromatic heterocycle and substituted 5-6-membered aromatic heterocycle, and R2 is selected from benzyl, C1-3 alkyl naphthyl, C1-3 alkyl, phenyl, substituted phenyl, 5-6-membered heteroaromatic ring and substituted 5-6-membered heteroaromatic ring. The compound disclosed by the invention can be strongly bonded with alpha-synuclein aggregate, can be used as an imaging tracer agent required by image examination technologies such as PET (Polyethylene Terephthalate) and SPECT (Single Photon Emission Computed Tomography) for clinical disease diagnosis or used for preparing the imaging tracer agent and preparing a composition comprising the imaging tracer agent, and used for detecting diseases related to alpha-synuclein misfolding and abnormal aggregation, such as Parkinson's disease, and has a remarkable good application prospect.

Malononitrile-activated synthesis and anti-cholinesterase activity of styrylquinoxalin-2(1: H)-ones

Herein, we report a base-free malononitrile activated condensation of 3-methylquinoxaline-2(1H)-one (3MQ) 1 with aryl aldehydes 3a-3ad for synthesis of styrylquinoxalin-2(1H)-ones (SQs) 4a-4ad with excellent yields. In this reaction, malononitrile activates the aldehyde via Knoevenagel condensation towards reaction with 3MQ 1 and gets liberated during the course of reaction to yield the desired SQs 4a-4ad. The SQs were evaluated for in vitro cholinesterase inhibition and 4n was found to display a mixed type of inhibition of AChE, which was supported by molecular modelling studies. This study has led to the discovery of a new chemotype for cholinesterase inhibition which might be useful in finding a remedy for Alzheimer's disease.

Radical Ions of 3-Styryl-quinoxalin-2-one Derivatives Studied by Pulse Radiolysis in Organic Solvents

The absorption-spectral and kinetic behaviors of radical ions and neutral hydrogenated radicals of seven 3-styryl-quinoxalin-2(1H)-one (3-SQ) derivatives, one without substituents in the styryl moiety, four others with electron-donating (R = -CH3/su

Experimental and theoretical studies for mild steel corrosion inhibition in 1.0 M HCl by three new quinoxalinone derivatives

Three quinoxalinone derivatives, namely (E)-3-styrylquinoxalin-2(1H)-one (SQ), (E)-3-(4-methoxystyryl)quinoxalin-2(1H)-one (MOSQ) and (E)-3-(4-methoxystyryl)-7-methylquinoxalin-2(1H)-one (MOSMQ) were synthesized and characterized. Thus, their inhibition e

Synthesis and in vivo diuretic activity of some new benzothiazole sulfonamides containing quinoxaline ring system

A series of new 6-substituted-N-[3-{2-(substituted phenyl)-ethenyl} quinoxaline-2(1H)-ylidene]-1,3-benzothiazole-2-amine (4a–f) were designed and synthesized by condensing 2-amino-benzothiazole-6-sulfonic acid amide (1) with chalcones of quinoxaline-2-one (3a–f) in a hope to obtain promising and a new class of diuretic agents. Structures of all the newly synthesized compounds were characterized by spectral data and elemental analysis. The pharmacological studies in experimental rats indicates that compound 4c possesses excellent in vivo diuretic activity of 1.13 and appears to be a better diuretic agent than the reference drugs, acetazolamide (1.0) and urea (0.88). Insight of the binding mode of the synthesized compounds (ligand) into the binding sites of carbonic anhydrase enzyme (PDF code: 4KUV) was provided by docking studies, performed with the help of Maestro 9.0 docking software. Further pharmacokinetic and toxicological studies are needed to confirm the safety of compound 4c which emerged as a lead diuretic compound.

Synthesis, characterization and biological evaluation of some heterocyclic compounds containing ethoxyphthalimide moiety via key intermediate 6-chloro 1,3 benzothiazole 2-amine

New and simple synthetic methods for the synthesis of ethyl 8-chloro-4(4-substitutedphenyl)-2-[(N-ethoxyphthalimido)amino]-4H-pyrimido[2, 1-b][1,3] benzothiazole-3-carboxylate 5a-d and 6-chloro-N-[3-{2-(4- substitutedphenyl)ethenyl}-1-N-ethoxyphthalimidoquinoxalin-2(1N)-ylidene]-1, 3-benzothiazol-2-amine 10a-d are described. 4-Chloroaniline 1 is converted to 6-chloro-1,3-benzothiazol-2-amine 2 by reaction with KSCN and Br2. Compound 2 acts as key intermediate for both the series of final compounds. In one pathway, 2 is converted to corresponding pyrimidothiazoles 4a-d by treatment with ethyl arylidinecyanoacetate 3a-d, which on condensation with phthalimidoxyethyl bromide 6 gives 5a-d. In a parallel route, reaction of 2 with 3-[2-(4-substituted phenyl)ethenyl]quinoxalin-2(1H)-one 8a-d affords 6-chloro-iV-[3-{2-(4-substituted phenyl)ethenyl} quinoxalin-2(1H)-ylidene]-1,3- benzothiazol-2-amine 9a-d which on condensation with phthalimidoxyethyl bromide 6, yields final compound 10a-d. Structure elucidation is accomplished by elemental analysis and spectral data of the synthesized compounds. Final compounds 5a-d and 10a-d have been screened in vitro for their antimicrobial activity against different strains of bacteria and fungi.

Reaction of Quinaxoline Derivatives with Nucleophilic Reagents

2-Chloro-3-methylquinoxaline reacts with aromatic amines in basic medium forming 2-arylamino-3-methylquinoxalines, also it reacts with mercaptoacetic acid.The 3-methyl-2(1H)-quinoxalinone condenses with aromatic aldehydes forming the corresponding 3-(subs