75479-32-2Relevant academic research and scientific papers
I2-Mediated Intramolecular C-H Amidation for the Synthesis of N-Substituted Benzimidazoles
Hu, Zhiyuan,Zhao, Ting,Wang, Manman,Wu, Jie,Yu, Wenquan,Chang, Junbiao
, p. 3152 - 3158 (2017/03/23)
A practical intramolecular C-H amidation methodology has been developed using molecular iodine under basic conditions. The required imine substrates were readily obtained by condensation of simple o-phenylenediamine derivatives and aldehydes. The transition-metal-free cyclization reaction described here works well with crude imines and allows for the sequential synthesis of N-protected benzimidazoles without purification of the less stable condensation intermediates. This operationally simple synthetic approach is broadly applicable to a variety of aromatic, aliphatic, and cinnamic aldehydes to produce diverse 1,2-disubstituted benzimidazole derivatives in an efficient and scalable fashion.
Palladium-catalyzed intramolecular sulfonamidation/oxidation of imines: Access to multifunctional benzimidazoles
Fu, Shaomin,Jiang, Huanfeng,Deng, Yuanfu,Zeng, Wei
, p. 2795 - 2804 (2011/12/01)
O-Sulfonamidophenylimines undergo intramolecular sulfonamidation/oxidation to produce 1,2-disubstituted benzimidazoles upon treatment with palladium(II) chloride/(diacetoxyiodo)benzene and potassium carbonate at room temperature. The substituent scope at
Studies on aroylation of o-phenylenediamine and subsequent reactions with electrophiles
Dubey,Kulkarni, Subhash M.,Vinod Kumar
, p. 1305 - 1309 (2007/10/03)
Condensation of o-phenylenediamine 1 with benzoyl chloride in pyridine results in the formation of dibenzoyl derivative 2 irrespective of the molar ratios employed. However, the reaction of 1 with arylsulphonyl chlorides gives a mono 3 and diarylsulphonyl
