75488-44-7

Basic information

• Product Name: 2-[1-(4-methylphenyl)ethenyl]thiophene
• Synonyms: 2-[1-(4-methylphenyl)ethenyl]thiophene
• CAS NO: 75488-44-7
• Molecular Weight: 200.304
• Mol File: 75488-44-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-[1-(4-methylphenyl)ethenyl]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[1-(4-methylphenyl)ethenyl]thiophene(75488-44-7)
• EPA Substance Registry System: 2-[1-(4-methylphenyl)ethenyl]thiophene(75488-44-7)

Safety Data

• Hazardous Substances Data: 75488-44-7(Hazardous Substances Data)

Upstream product

• 5713-61-1 thiophen-2-yl magnesium bromide 
• 122-00-9 para-methylacetophenone 
• 1003-09-4 2-bromothiophene 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 6933-25-1 2-thienyl 4-methylphenyl ketone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 106-38-7 para-bromotoluene 
• 1176196-09-0 1-thiophen-2-yl-1-p-tolylethanol 
• 88-15-3 2-Acetylthiophene 
• 4294-57-9 para-methylphenylmagnesium bromide 

Downstream Products

• 1343477-52-0 2,2,2-trifluoro-1-[5-(4-methylphenyl)-2,5-di(thiophen-2-yl)-4,5-dihydrofuran-3-yl]ethanone 
• 1343477-54-2 2,2,2-trifluoro-1-[5-(4-methylphenyl)-2-phenyl-5-(thiophen-2-yl)-4,5-dihydrofuran-3-yl]ethanone 
• 1343477-53-1 2,2,3,3,4,4,4-heptafluoro-1-[5-(4-methylphenyl)-2,5-di(thiophen-2-yl)-4,5-dihydrofuran-3-yl]butan-1-one 
• 6933-25-1 2-thienyl 4-methylphenyl ketone 

Relevant articles and documents

Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System

A green Barluenga-Valdés cross-coupling reaction for the synthesis of 1,1-diarylethylenes using palladium catalysis has been developed. The new catalytic system based on Pd/Xphos-SO3Na or Pd/MeDavephos-CF3SO3 in PEG/H2O under microwave irradiation was found to be the best conditions for this transformation. The recyclability of the palladium catalyst system was also studied, and it was found to be active over nine runs without significant loss in its activity.

Synthesis of dihydrofurans containing trifluoromethyl ketone and heterocycles by radical cyclization of fluorinated 1,3-dicarbonyl compounds with 2-thienyl and 2-furyl substituted alkenes

Manganese(III) acetate based radical cyclization of various fluorinated 1,3-dicarbonyl compounds with 2-thienyl and 2-furyl substituted alkenes produced 3-trifluoroacetyl and 2-trifluoromethyl-dihydrofurans in good yields. The radical cyclizations of 2-methyl-5-[(E)-2-phenylvinyl]furan 2b and 2-[(E)-2-phenylvinyl]thiophene 2c led to the formations of 5-(5-methyl-2-furyl)- 4,5-dihydrofuran and 5-(2-thienyl)-4,5-dihydrofuran, respectively. In the reactions of 1,3-dicarbonyls with alkenes, 2-thienyl substituted alkenes formed 4,5-dihydrofurans in higher yields than 2-furyl substituted alkenes.