75488-44-7

Upstream product

• 88-15-3 2-Acetylthiophene 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 122-00-9 para-methylacetophenone 
• 1003-09-4 2-bromothiophene 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 6933-25-1 2-thienyl 4-methylphenyl ketone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 106-38-7 para-bromotoluene 
• 1176196-09-0 1-thiophen-2-yl-1-p-tolylethanol 

Downstream Products

• 75488-23-2 4-p-tolylanthra<2,1-b>thiophene-6,11-dione 
• 75488-24-3 2-methyl-5-(2-thienyl)benzanthracene-7,12-dione 
• 1343477-52-0 2,2,2-trifluoro-1-[5-(4-methylphenyl)-2,5-di(thiophen-2-yl)-4,5-dihydrofuran-3-yl]ethanone 
• 1343477-54-2 2,2,2-trifluoro-1-[5-(4-methylphenyl)-2-phenyl-5-(thiophen-2-yl)-4,5-dihydrofuran-3-yl]ethanone 
• 1343477-53-1 2,2,3,3,4,4,4-heptafluoro-1-[5-(4-methylphenyl)-2,5-di(thiophen-2-yl)-4,5-dihydrofuran-3-yl]butan-1-one 
• 1378021-24-9 3,5,6,7-tetrahydro-2-(4-methylphenyl)-6-phenyl-2-(2-thienyl)benzofuran-4(2H)-one 
• 1378021-22-7 ethyl 4,5-dihydro-2-methyl-5-(4-methylphenyl)-5-(2-thienyl)furan-3-carboxylate 
• 1378021-23-8 3,5,6,7-tetrahydro-6,6-dimethyl-2-(4-methylphenyl)-2-(2-thienyl)benzofuran-4(2H)-one 
• 1378021-21-6 4,5-dihydro-1-[2-methyl-5-(4-methylphenyl)-5-(2-thienyl)furan-3-yl]ethanone 
• 1378021-38-5 [4,5-dihydro-2-methyl-5-(4-methylphenyl)-5-(2-thienyl)furan-3-yl]phenylmethanone 
• 1378021-39-6 1-[4,5-dihydro-5-(4-methylphenyl)-2-phenyl-5-(2-thienyl)furan-3-yl]ethanone 

Relevant academic research and scientific papers

Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System

A green Barluenga-Valdés cross-coupling reaction for the synthesis of 1,1-diarylethylenes using palladium catalysis has been developed. The new catalytic system based on Pd/Xphos-SO3Na or Pd/MeDavephos-CF3SO3 in PEG/H2O under microwave irradiation was found to be the best conditions for this transformation. The recyclability of the palladium catalyst system was also studied, and it was found to be active over nine runs without significant loss in its activity.

Pyridine-directed asymmetric hydrogenation of 1 1-diarylalkenes

Highly enantioselective pyridine-directed rhodium-catalyzed asymmetric hydrogenation of challenging 1 1-diarylalkenes is achieved by using [Rh(NBD)DuanPhos]BF4 as a precatalyst. Various types of 2-pyridine substituted 1 1-diarylalkenes could be hydrogenated with good to excellent enantioselectivities which provide an efficient route to the synthesis of pharmaceutically and biologically active compounds containing a 2-pyridyl ethane unit.

Synthesis of dihydrofurans containing trifluoromethyl ketone and heterocycles by radical cyclization of fluorinated 1,3-dicarbonyl compounds with 2-thienyl and 2-furyl substituted alkenes

Manganese(III) acetate based radical cyclization of various fluorinated 1,3-dicarbonyl compounds with 2-thienyl and 2-furyl substituted alkenes produced 3-trifluoroacetyl and 2-trifluoromethyl-dihydrofurans in good yields. The radical cyclizations of 2-methyl-5-[(E)-2-phenylvinyl]furan 2b and 2-[(E)-2-phenylvinyl]thiophene 2c led to the formations of 5-(5-methyl-2-furyl)- 4,5-dihydrofuran and 5-(2-thienyl)-4,5-dihydrofuran, respectively. In the reactions of 1,3-dicarbonyls with alkenes, 2-thienyl substituted alkenes formed 4,5-dihydrofurans in higher yields than 2-furyl substituted alkenes.

A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite

The widely available carbonyl compounds react with Grignard reagents in the presence of diethyl phosphite to give the corresponding olefins in good to excellent yields: A range of conjugated dienes, terminal olefins, multisubstituted-alkenes and conjugated enynes could be readily obtained by the method in mild conditions.