754944-16-6 Usage
Description
4-Chloro-2-fluoro-di-phenylalanine is a synthetic chemical compound with the molecular formula C18H15ClFNO2. It is a derivative of phenylalanine, an essential amino acid that plays a crucial role in protein synthesis. Characterized by the presence of a chlorine and a fluorine atom on the phenylalanine molecule, this compound exhibits unique properties that make it a subject of interest in pharmaceutical research. Its potential applications in drug development and medicinal chemistry are significant, particularly in the design of new pharmaceuticals with enhanced pharmacological properties.
Uses
Used in Pharmaceutical Research and Development:
4-Chloro-2-fluoro-di-phenylalanine is utilized as a key building block in the synthesis of novel pharmaceuticals. Its unique structural features allow for the development of drugs with improved pharmacological properties, such as increased potency, selectivity, and reduced side effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Chloro-2-fluoro-di-phenylalanine serves as a valuable component in the design and optimization of new drug candidates. Its presence in molecular structures can influence the binding affinity, stability, and overall performance of potential therapeutic agents.
Used in Drug Design:
4-Chloro-2-fluoro-di-phenylalanine is employed as a structural modifier in drug design, enabling the creation of molecules with tailored properties. Its incorporation into drug candidates can lead to enhanced biological activity, improved pharmacokinetics, and reduced toxicity.
Used in Biochemical Studies:
4-Chloro-2-fluoro-di-phenylalanine is also used in biochemical research to investigate the effects of structural modifications on protein function and stability. Understanding the impact of 4-Chloro-2-fluoro-di-phenylalanine on protein behavior can provide insights into the development of targeted therapies and the study of protein-related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 754944-16-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,4,9,4 and 4 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 754944-16:
(8*7)+(7*5)+(6*4)+(5*9)+(4*4)+(3*4)+(2*1)+(1*6)=196
196 % 10 = 6
So 754944-16-6 is a valid CAS Registry Number.
754944-16-6Relevant articles and documents
Enantioselective syntheses of no-carrier-added (n.c.a.) (S)-4-chloro-2-[18F] fluorophenylalanine and (S) - (α-methyl) -4-chloro-2-[18F]fluorophenylalanine
Al-Darwich,Plenevaux,Lemaire,Fiore,Christiaens,Comar,Luxen
, p. 117 - 124 (1996)
(S)-4-Chloro-2-fluorophenylalanine and (S)-(α-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F]fluorobenzyl iodide and the lithium enolate of (2S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3-methyl-1,3-imidazolidine-4-one for (S)-4-chloro-2-[18F]fluorophenylalanine and (2S,5S)-1-(tert-butyloxycarbonyl)-2-(tert-butyl)-3,5-dimethyl-1,3-imidazolidine-4-one for (S) - (α-methyl)-4-chloro-2-[18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F]fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better.
