754978-60-4

Upstream product

• 207606-87-9 1,2-di-O-isopropylidene-3,5-di-O-benzyl-3-C-vinyl-α-D-ribofuranose 

Downstream Products

• 754978-61-5 1-(2-O-acetyl-3-C-(benzoyloxy)methyl-3,5-di-O-benzyl-β-D-ribofuranosyl)thymine 
• 1239479-15-2 3-C-azidomethyl-3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranose 
• 858128-95-7 3,5-di-O-benzyl-1,2-di-O-isopropylidene-3-C-(methanesulfonyloxymethyl)-α-D-ribofuranose 

Relevant academic research and scientific papers

An α-D-configured bicyclic nucleoside restricted in an E-type conformation: Synthesis and parallel RNA recognition

An α-D-arabino configured bicyclic nucleoside strongly restricted in an E-type conformation by a 2′-3′-fused oxetane ring is synthesized. Several synthetic strategies toward the target compound are described, and the successful preparation from a D-xylose

New ruthenium-based protocol for cleavage of terminal olefins to primary alcohols: Improved synthesis of a bicyclic nucleoside

A new protocol for the oxidative cleavage of terminal alkenes to give exclusively primary alcohols in high yields is introduced. The protocol is based on RuO4-mediated dihydroxylation, NaIO4-mediated diol cleavage, and NaBH4-mediated reduction, but the introduction of a reducing step before the diol cleavage removes the formation of byproducts and improves the yield significantly. The new protocol has been developed and used for the improved preparation of a [3.2.0]bicycloarabinonucleoside with important potential in antisense and antigene technology.