858128-95-7

Upstream product

• 754978-60-4 3,5-di-O-benzyl-1,2-di-O-isopropylidene-3-C-hydroxymethyl-α-D-ribofuranose 
• 124-63-0 methanesulfonyl chloride 
• 207606-87-9 1,2-di-O-isopropylidene-3,5-di-O-benzyl-3-C-vinyl-α-D-ribofuranose 

Downstream Products

• 1239479-07-2 3-C-fluoromethyl-3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-ribofuranose 

Relevant academic research and scientific papers

Synthesis and anti-hepatitis C virus (HCV) activity of 3′-C- substituted-methyl pyrimidine and purine nucleosides

On the basis of potent anti-hepatitis C virus (HCV) activity of 2′-C-hydroxymethyladenosine, 3′-C-substituted-methyl-ribofuranosyl pyrimidine and purine nucleosides were designed and synthesized from d-xylose. Among compounds tested, all adenine analogues, 4a, 4d, and 4g showed significant anti-HCV activity in a replicon-based cell assay irrespective of the substituent (Y = OH, N3, or F) at the 3′-C-substituted methyl position, among which 4g (Y = N3) was the most potent, but it is also cytotoxic. This study guarantees the 3′-C-substituted-methyl nucleoside serves as a new template for the development of new anti-HCV agents.

An α-D-configured bicyclic nucleoside restricted in an E-type conformation: Synthesis and parallel RNA recognition

An α-D-arabino configured bicyclic nucleoside strongly restricted in an E-type conformation by a 2′-3′-fused oxetane ring is synthesized. Several synthetic strategies toward the target compound are described, and the successful preparation from a D-xylose