75500-04-8

Upstream product

• 34001-56-4 1,3-dibenzyluracil 
• 100-39-0 benzyl bromide 
• 504-07-4 5,6-dhydrouracil 

Downstream Products

• 532413-11-9 (R)-1,3-Dibenzyl-5-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-dihydro-pyrimidine-2,4-dione 
• 532413-10-8 (S)-1,3-Dibenzyl-5-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-dihydro-pyrimidine-2,4-dione 
• 532413-12-0 (R)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione 
• 532413-13-1 (S)-1,3-Dibenzyl-5-[(S)-(tert-butyl-dimethyl-silanyloxy)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl]-dihydro-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Iridium-Catalyzed β-C(sp2)?H Borylation of Enamides – Access to 3,3-Dihalogeno-2-methoxypiperidines

An efficient catalytic preparation of synthetically useful new β-borylated enamides was achieved under relatively mild conditions via a regioselective iridium-catalyzed C(sp2)?H borylation. The method features broad substrate scope, good functi

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

Ammonium formate/palladium on carbon: A versatile system for catalytic hydrogen transfer reductions of carbon-carbon double bonds

Various carbon-carbon double bonds in olefins and α,β -unsaturated ketones were effectively reduced to the corresponding alkanes and saturated ketones, using ammonium formate as a hydrogen transfer agent in the presence of Pd/C as catalyst in refluxing methanol.

Use of 1,3-dibenzyl-dihydrouracil in the chain extension of 2,3-O-isopropylidene-D-glyceraldehyde

The aldol-type addition of 1,3-dibenzyl-dihydrouracil 2 to 2,3-O-isopropylidene-D-glyceraldehyde 3 was examined in different solvents and under Lewis acid catalysis in order to establish the stereochemical preferences. A stereodivergent synthesis of 5-trihydroxypropyl-dihydrouracil derivatives 4 and its C-5 epimer 5 was realized. The synthesis of ureido polyols 8 and 10 was obtained via the reductive ring opening of the templates 4 and 5.

Studies on Uracil Derivatives and Analogues. Part 8. A Non-catalytic Method for the Conversion of Uracil Derivatives into Dihydrouracil Derivatives

A mild and highly efficient method for the reduction of the 5,6-double bond of N-alkylated uracils with lithium tri-s-buthylborohydride gives the corresponding 5,6-dihydro derivatives.The method can also be used for alkylation of the 5-position of N-alkyluracils to give 5-alkyl-5,6-dihydrouracil derivatives.

A new synthesis of n-blocked dihydrouracil and dihydroorotic acid derivatives using lithium tri-sec-butyl borohydride as reducing agent

1,3-Di-N-substituted uracil and its derivatives have been reduced with lithium-tri-sec-butyl borohydride to the corresponding 5,6-dihydro compounds in excellent yields. Alkylation of 5-position of uracil is also very conveniently accomplished.