75500-05-9Relevant academic research and scientific papers
Studies on Uracil Derivatives and Analogues. Part 8. A Non-catalytic Method for the Conversion of Uracil Derivatives into Dihydrouracil Derivatives
Kundu, Nitya G.,Sikdar, Sikha,Hertzberg, Robert P.,Schmitz, Scott A.,Khatri, Surenda G.
, p. 1295 - 1300 (2007/10/02)
A mild and highly efficient method for the reduction of the 5,6-double bond of N-alkylated uracils with lithium tri-s-buthylborohydride gives the corresponding 5,6-dihydro derivatives.The method can also be used for alkylation of the 5-position of N-alkyluracils to give 5-alkyl-5,6-dihydrouracil derivatives.
A new synthesis of n-blocked dihydrouracil and dihydroorotic acid derivatives using lithium tri-sec-butyl borohydride as reducing agent
Hannon, Stephen J.,Kundu, Nitya G.,Hertzberg, Robert P.,Bhatt, Ram S.,Heidelberger, Charles
, p. 1105 - 1108 (2007/10/02)
1,3-Di-N-substituted uracil and its derivatives have been reduced with lithium-tri-sec-butyl borohydride to the corresponding 5,6-dihydro compounds in excellent yields. Alkylation of 5-position of uracil is also very conveniently accomplished.
