75500-12-8Relevant academic research and scientific papers
Improved chemical syntheses of 5,6-dihydro-5-fluorouracil
LaFrate, Andrew L.,Katzenellenbogen, John A.
, p. 8573 - 8576 (2008/02/13)
(Chemical Equation Presented) 5,6-Dihydro-5-fluorouracil (5-DHFU) is a metabolite of the chemotherapy drug 5-fluorouracil (5-FU) of importance for biological studies. 5-DHFU has been prepared by enzymatic reduction of 5-FU and in very low yield by hydrogenation of 5-FU; however, a practical chemical synthesis is not available. Facile racemic syntheses of 5-DHFU from 5-FU or uracil, using p-methoxybenzyl protecting groups followed by L-Selectride reduction, are reported.
Studies on Uracil Derivatives and Analogues. Part 8. A Non-catalytic Method for the Conversion of Uracil Derivatives into Dihydrouracil Derivatives
Kundu, Nitya G.,Sikdar, Sikha,Hertzberg, Robert P.,Schmitz, Scott A.,Khatri, Surenda G.
, p. 1295 - 1300 (2007/10/02)
A mild and highly efficient method for the reduction of the 5,6-double bond of N-alkylated uracils with lithium tri-s-buthylborohydride gives the corresponding 5,6-dihydro derivatives.The method can also be used for alkylation of the 5-position of N-alkyluracils to give 5-alkyl-5,6-dihydrouracil derivatives.
A new synthesis of n-blocked dihydrouracil and dihydroorotic acid derivatives using lithium tri-sec-butyl borohydride as reducing agent
Hannon, Stephen J.,Kundu, Nitya G.,Hertzberg, Robert P.,Bhatt, Ram S.,Heidelberger, Charles
, p. 1105 - 1108 (2007/10/02)
1,3-Di-N-substituted uracil and its derivatives have been reduced with lithium-tri-sec-butyl borohydride to the corresponding 5,6-dihydro compounds in excellent yields. Alkylation of 5-position of uracil is also very conveniently accomplished.
