755008-23-2Relevant academic research and scientific papers
Solid-phase synthesis of complex oligosaccharides using azidoglucose as a glycosyl acceptor
Wu, Xiangyang,Schmidt, Richard R.
, p. 2826 - 2832 (2004)
The solid phase synthesis of oligosaccharides 1-3 was performed on Merrifield resin. These syntheses are based on the hydroxymethylbenzyl benzoate spacer-linker system and, for regioselective chain extension, the use of O-glycosyl trichloroacetimidates as glycosyl donors containing temporary O-Fmoc protection. The important lactosamine-containing oligosaccharides 1-3 are accessible in excellent yields by using a 2-azidoglucose residue as the glucosamine building block adjacent to the spacer-linker system. Only standard amounts of the glycosyl donor are employed in this solid phase oligosaccharide synthesis and we did not have to resort to any capping procedures. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
