7555-68-2Relevant academic research and scientific papers
Gem-Difluorination of Methylenecyclopropanes (MCPs) Featuring a Wagner-Meerwein Rearrangement: Synthesis of 2-Arylsubstituted gem-Difluorocyclobutanes
Lin, Peng-Peng,Huang, Long-Ling,Feng, Si-Xin,Yang, Shuang,Wang, Honggen,Huang, Zhi-Shu,Li, Qingjiang
, p. 3088 - 3093 (2021)
The geminal difluorocyclobutane core is a valuable structural element in medicinal chemistry. Strategies for gem-difluorocyclobutanes, especially the 2-substituted cases, are limiting and often suffer from harsh reaction conditions. Reported herein is a m
Rhodium-Catalyzed Ring-Opening Hydroacylation of Alkylidenecyclopropanes with Chelating Aldehydes for the Synthesis of γ,δ-Unsaturated Ketones
Li, Hong-Shuang,Lu, Shi-Chao,Chang, Zhi-Xin,Hao, Liqiang,Li, Fu-Rong,Xia, Chengcai
supporting information, p. 5145 - 5150 (2020/07/04)
The first intermolecular ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes through a rhodium-catalyzed acrylamide-promoted protocol is reported. This highly efficient catalytic system enables the direct synthesis of a diverse
Visible light-induced palladium-catalyzed ring opening β-H elimination and addition of cyclobutanone oxime esters
Xing, Wei-Long,Shang, Rui,Wang, Guang-Zu,Fu, Yao
supporting information, p. 14291 - 14294 (2019/12/02)
A palladium catalyst under visible light irradiation activates cyclobutanone oxime ester through single electron transfer to induce radical ring opening to generate hybrid cyanoalkyl Pd(i) radical species. Hybrid cyanoalkyl Pd(i) radical species can undergo either β-H elimination to deliver (E)-4-arylbut-3-enenitrile or undergo radical addition with silyl enol ether and enamide to generate δ-cyano ketones. A dual ligand system composed of two phosphine ligands is essential for the high reactivity.
