75562-60-6Relevant academic research and scientific papers
Zinc-Mediated Allylation Followed by Lactonization of Dialkyl 2-(3-Oxo-1,3-diarylpropyl)malonates: Construction of δ-Lactones with Multiple Stereocenters
Reddy, Chennakesava,Babu, Srinivasarao Arulananda
supporting information, p. 2121 - 2126 (2015/09/15)
A variety of polysubstituted δ-lactones containing three or four stereocenters were prepared from various dialkyl 2-(3-oxo-1,3-diarylpropyl)malonates by a Barbier-type zinc-mediated allylation or cyclohexenylation of the keto group, followed by intramolec
THERAPEUTIC AGENT FOR DIABETES
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, (2008/06/13)
A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.
The Reaction between Dimetyl 2-Bromo-1-phenylpropylidenemalonate and Sodium Methoxide in Methanol; Formation of a Cyclopropene by an Addition-Elimination Reaction
Berg, Arne S.
, p. 241 - 248 (2007/10/02)
The reaction between dimethyl 2-bromo-1-phenylpropylidenemalonate and sodium methoxide in methanol has been investigated.If the reaction is run at room tempareture for 25 h, dimethyl 2-methyl-3-phenyl-2-cyclopropene-1,1-dicarboxylate is formed in 19percen
